ArticlePloS one2018
Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Genetic Basis of Elongated Tails in Birds: Evidence for Sexual Selection as a Driver of Convergent Evolution.Integrative zoology · 2026Article
- Transcriptome and Weighted Gene Co-Expression Network Analysis for Feather Follicle Density in a Chinese Indigenous Breed.Animals : an open access journal from MDPI · 2024Article
- Article
- Review
- Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose.Animals : an open access journal from MDPI · 2022Article
- The Dynamic Change of Gene-Regulated Networks in Cashmere Goat Skin with Seasonal Variation.Biochemical genetics · 2022Article
- Review
- Transcriptome Comparison Reveals Key Components of Nuptial Plumage Coloration in Crested Ibis.Biomolecules · 2020Article
- Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.PLoS biology · 2019Article
- Combined transcriptomics and proteomics forecast analysis for potential genes regulating the Columbian plumage color in chickens.PloS one · 2019Article
- An ancient Turing-like patterning mechanism regulates skin denticle development in sharks.Science advances · 2018Article
- Genetic and Molecular Basis of Feather Diversity in Birds.Genome biology and evolution · 2018Review
Corrections and comments
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Avian species have a unique integument covered with feathers. Skin morphogenesis is a successive and complex process. To date, most studies have focused on a single developmental point or stage. Fewer studies have focused on whole transcriptomes based on the time-course of embryo integument development. To analyze the global changes in gene expression profiles, we sequenced the transcriptome of chicken embryo skin samples from day 6 to day 21 of incubation and identified 5830 differentially expressed genes (DEGs). Hierarchical clustering showed that E6 to E14 is the critical period of feather follicle morphogenesis. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the DEGs, two kinds of Wnt signaling pathways (a canonical pathway and a non-canonical pathway) changed during feather follicle and feather morphogenesis. The gene expression level of inhibitors and ligands related to the Wnt signaling pathway varied significantly during embryonic development. The results revealed a staggered phase relationship between the canonical pathway and the non-canonical pathway from E9 to E14. These analyses shed new light on the gene regulatory mechanism and provided fundamental data related to integument morphogenesis of chickens.
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