ArticleJournal of clinical gastroenterology2019
Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals.
Article in Journal of clinical gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial.JMIR mHealth and uHealth · 2021Trial
- Effect of Stretching on the Electroencephalography of People With Irritable Bowel Syndrome.Cureus · 2025Article
- Sexual function, depression, and quality of life in patients with irritable bowel syndrome.BMC gastroenterology · 2025Article
- Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology.Nutrients · 2025Review
- Psychological determinants of irritable bowel syndrome and its impact on quality of life: a machine learning approaches.Gastroenterology and hepatology from bed to bench · 2025Article
- The association between the Mediterranean Diet and the prime diet quality score and new-diagnosed irritable bowel syndrome: a matched case-control study.Frontiers in medicine · 2025Article
- Microbiome Shifts and Their Impact on Gut Physiology in Irritable Bowel Syndrome.International journal of molecular sciences · 2024Review
- Quality of Life and Its Psychosocial Predictors among Patients with Disorders of Gut-Brain Interaction: A Comparison with Age- and Sex-Matched Controls.Healthcare (Basel, Switzerland) · 2024Article
- Psychological factors may affect the quality of life in irritable bowel syndrome patients more than the gut itself? A multicenter cross-sectional study.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Comparison of the Effectiveness of Mindfulness-Based Stress Reduction and Compassion-Focused Treatment on the Severity of Gastrointestinal Symptoms in Patients with Irritable Bowel Syndrome.Middle East journal of digestive diseases · 2024Article
- The Association Between a Mediterranean Diet and Symptoms of Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Alexithymia impairs quality of life in irritable bowel syndrome.Future science OA · 2023Article
- Symptom management needs of patients with irritable bowel syndrome and concurrent anxiety and/or depression: A qualitative study.Journal of advanced nursing · 2023Article
- Association between body mass index and irritable bowel syndrome in the young Japanese population: a cross-sectional study.International journal of colorectal disease · 2022Article
- The impact of treatment with bile acid sequestrants on quality of life in patients with bile acid diarrhoea.BMC gastroenterology · 2022Article
- The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.Cellular and molecular neurobiology · 2022Review
- Effect of Exclusion Diets on Symptom Severity and the Gut Microbiota in Patients With Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- A neuropsychosocial signature predicts longitudinal symptom changes in women with irritable bowel syndrome.Molecular psychiatry · 2022Article
- Article
- Patient preferences of healthcare delivery in irritable bowel syndrome: a focus group study.BMC gastroenterology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIrritable bowel syndrome (IBS) reduces health-related quality of life (HRQOL). It is unclear how having IBS modifies the impact of gastrointestinal (GI), psychosocial, and somatic symptom variables on HRQOL compared with healthy controls (HCs).
aims(1) Determine psychosocial, somatic, and physical status variables most predictive of HRQOL in IBS and HCs and (2) determine if IBS status modifies relationships between predictive factors and HRQOL.
methodsIBS patients and HCs completed validated questionnaires measuring GI symptoms, psychosocial/somatic variables, and physical [physical component score (PCS)] and mental [mental component score (MCS)] HRQOL via the Short-Form-36. Associations between these variables and HRQOL were evaluated with multiple linear regressions. Variables were standardized to determine the strongest predictors of HRQOL. Statistical significance level was 0.01.
resultsMean HRQOL was higher in 417 HCs versus 290 IBS subjects (PCS: 55.6 vs. 48.6, P<0.001; MCS: 53.7 vs. 44.8, P<0.001). The GI symptom measures were negatively associated with PCS in IBS, but only usual severity was associated with MCS (P<0.01). In all subjects, psychosocial and somatic measures were associated with MCS and not PCS excluding GI symptom anxiety, which correlated with both (P<0.01). The strongest predictor of MCS was perceived stress in IBS and depression symptoms in HCs. GI symptom anxiety was the strongest predictor of PCS in both. Greater perceived stress and somatic symptom severity and less mindfulness was linked to larger reductions in HRQOL for IBS compared with HCs (P<0.01).
conclusionsGI symptom severity and anxiety correlate with PCS, whereas psychosocial/somatic measures parallel MCS. However, HRQOL is comparable in IBS and HCs when perceived stress, somatic symptom severity, and mindfulness are at optimal levels. These findings may have important implications in the management of IBS.
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