Evidence map›Paper›PMID 29350887›Full record

Observational studyInfluenza and other respiratory viruses2018

Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults.

Monique Bouvier, Wei-Ju Chen, John C Arnold, Mary P Fairchok, Patrick J Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H Burgess and 1 more

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Breath Biomarkers of Influenza Infection.Open forum infectious diseases · 2022
    Article
  5. Article
  6. Gastrointestinal manifestations in COVID-19.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021
    Review
  7. Codon usage analysis of zoonotic coronaviruses reveals lower adaptation to humans by SARS-CoV-2.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Severity of coronavirus respiratory tract infections in adults admitted to acute care in Toronto, Ontario.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  14. Children in Coronaviruses' Wonderland: What Clinicians Need to Know.Mediterranean journal of hematology and infectious diseases · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Monique BouvierBetty Irene Moore School of Nursing, University of California Davis, Sacramento, CA, USA.
Wei-Ju ChenDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
John C ArnoldNaval Medical Center, San Diego, CA, USA.
Mary P FairchokDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Patrick J DanaherSan Antonio Military Medical Center, San Antonio, TX, USA.
Tahaniyat LalaniDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Leslie MaloneDiatherix Laboratories, LLC, Huntsville, AL, USA.
Deepika MorDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Michelande RidoréChildren's National Medical Center, Washington, DC, USA.
Timothy H BurgessDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Eugene V MillarDepartment of Preventive Medicine and Biostatistics, Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-2019-6480
Henry M. Jackson Foundation · USBrooke Army Medical Center · USChildren's National · USIDEXX Laboratories (France) · FRNaval Medical Center San Diego · USUC Davis Health · USUniformed Services University of the Health Sciences · US

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
–
NIAID NIH HHS Y01 AI005072
6 · The paper itself

Abstract

Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

Indexed as

AdolescentAdultAgedAlphacoronavirusBetacoronavirusCoronavirus InfectionsFemaleGastrointestinal DiseasesHumansLongitudinal StudiesMaleMiddle AgedPolymerase Chain ReactionRespiratory Tract InfectionsRNA, ViralYoung AdultRNA, Viralclinical characteristicscoronavirusinfluenza-like illness

Identifiers

PMID29350887
PMCPMC5820427
OpenAlexW2793400825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.