ArticleJournal of biomechanical engineering2018
Preventing Mesh Pore Collapse by Designing Mesh Pores With Auxetic Geometries: A Comprehensive Evaluation Via Computational Modeling.
Article in Journal of biomechanical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- In Silico Evaluation of an Elastomeric Membrane for Prolapse Repairs.Urogynecology (Philadelphia, Pa.) · 2026Article
- Comparative finite element modelling of surgical meshes at macro and mesoscale: assessing the role of morphology on mechanical behavior.Medical & biological engineering & computing · 2026Article
- Article
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Significance of Textile Properties for the Design of a New Pelvic Implant to Treat Pelvic Organ Prolapse.International urogynecology journal · 2025Review
- Assessing the Impact of Morphological Parameters on the Mechanical Behavior of Synthetic Meshes. A Multivariate Regression Approach.International journal for numerical methods in biomedical engineering · 2025Article
- Innovative Strategies in Hernia Mesh Design: Materials, Mechanics, and Modeling.Materials (Basel, Switzerland) · 2025Review
- Polypropylene surgical mesh induces lipid oxidation in a nonhuman primate model.Acta biomaterialia · 2025Article
- 3D Printed Mesh Geometry Modulates Immune Response and Interface Biology in Mouse and Sheep Model: Implications for Pelvic Floor Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Finite element modeling in obstetrics and gynecology: advances, applications, and challenges.Frontiers in medicine · 2025Review
- Auxetic Biomedical Metamaterials for Orthopedic Surgery Applications: A Comprehensive Review.Orthopaedic surgery · 2024Review
- Deformation and Durability of Soft Three-Dimensional-Printed Polycarbonate Urethane Porous Membranes for Potential Use in Pelvic Organ Prolapse.Journal of biomechanical engineering · 2023Article
- Nanocellulose: Recent Advances Toward Biomedical Applications.Small science · 2023Article
- The influence of the combined impairments and apical mesh surgery on the biomechanical behavior of the pelvic floor system.Frontiers in bioengineering and biotechnology · 2023Article
- Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices.ACS polymers Au · 2022Article
- Complications related to use of mesh implants in surgical treatment of stress urinary incontinence and pelvic organ prolapse: infection or inflammation?World journal of urology · 2020Review
- Landmarks in vaginal mesh development: polypropylene mesh for treatment of SUI and POP.Nature reviews. Urology · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Pelvic organ prolapse (POP) meshes are exposed to predominately tensile loading conditions in vivo that can lead to pore collapse by 70-90%, decreasing overall porosity and providing a plausible mechanism for the contraction/shrinkage of mesh observed following implantation. To prevent pore collapse, we proposed to design synthetic meshes with a macrostructure that results in auxetic behavior, the pores expand laterally, instead of contracting when loaded. Such behavior can be achieved with a range of auxetic structures/geometries. This study utilized finite element analysis (FEA) to assess the behavior of mesh models with eight auxetic pore geometries subjected to uniaxial loading to evaluate their potential to allow for pore expansion while simultaneously providing resistance to tensile loading. Overall, substituting auxetic geometries for standard pore geometries yielded more pore expansion, but often at the expense of increased model elongation, with two of the eight auxetics not able to maintain pore expansion at higher levels of tension. Meshes with stable pore geometries that remain open with loading will afford the ingrowth of host tissue into the pores and improved integration of the mesh. Given the demonstrated ability of auxetic geometries to allow for pore size maintenance (and pore expansion), auxetically designed meshes have the potential to significantly impact surgical outcomes and decrease the likelihood of major mesh-related complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.