Evidence map›Paper›PMID 29350614›Full record

ArticleeLife2018

LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer.

Pang-Kuo Lo, Yuan Yao, Ji Shin Lee, Yongshu Zhang, Weiliang Huang, Maureen A Kane, Qun Zhou

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
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  6. Article
  7. ISGylation: is our genome yearning for such a modification?Acta biochimica et biophysica Sinica · 2025
    Review
  8. Article
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  15. Article
  16. The Functional Roles of ISG15/ISGylation in Cancer.Molecules (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pang-Kuo LoDepartment of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0001-7202-3162
Yuan YaoDepartment of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, United States.
Ji Shin LeeDepartment of Pathology, Chonnam National University Medical School, Gwangju, Korea.
Yongshu ZhangDepartment of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, United States.
Weiliang HuangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, United States.
Maureen A KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, United States.
Qun ZhouDepartment of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0003-1745-0369
University of Maryland, Baltimore · USChonnam National University Hospital · KR

Funding

miR-140 and Breast Cancer PreventionR01CA163820 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHOU, QUN · 2012 to 2016
$1.6M
Shikonin and Nrf2 ChemopreventionR01CA157779 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHOU, QUN · 2013 to 2017
$1.4M
NCI NIH HHS CA157779A1NCI NIH HHS CA163820A1NCI NIH HHS R01 CA157779NCI NIH HHS R01 CA163820
6 · The paper itself

Abstract

Current understanding of aggressive human basal-like triple-negative breast cancer (TNBC) remains incomplete. In this study, we show endothelial lipase (LIPG) is aberrantly overexpressed in basal-like TNBCs. We demonstrate that LIPG is required for

Indexed as

CarcinogenesisSignal TransductionCell MovementCell ProliferationCytokinesEpithelial-Mesenchymal TransitionHumansLipaseNeoplasm MetastasisTriple Negative Breast NeoplasmsUbiquitin-Protein LigasesUbiquitinsCytokinesDTX3L protein, humanISG15 protein, humanLipaseLIPG protein, humanUbiquitin-Protein LigasesUbiquitinsBasal-like TNBCcancer biologyDTX3Lendothelial lipasehumanISG15LIPGmouse

Identifiers

PMID29350614
PMCPMC5809145
OpenAlexW2783318624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.