ArticlePediatric blood & cancer2018
Bleeding and thrombotic complications of pediatric liver transplant.
Article in Pediatric blood & cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Heparin continuous infusion for thromboprophylaxis in pediatric liver transplant recipients.Frontiers in pediatrics · 2026Article
- Analysis of factor concentrates in pediatric patients undergoing living donor liver transplantation: a retrospective, propensity-matched study.BMC anesthesiology · 2025Article
- Characterization of emergency department visits in pediatric patients within first year of liver transplantation: ten years experience in tertiary care center.BMC emergency medicine · 2025Observational
- Progress of pediatric liver transplantation: In Japan and beyond.Chinese medical journal · 2025Review
- Persisting thrombomodulin resistance at 3 months after liver transplantation in children with cirrhosis.Research and practice in thrombosis and haemostasis · 2025Article
- Post-operative heparin reduces early venous thrombotic complications after orthotopic paediatric liver transplantation.Blood transfusion = Trasfusione del sangue · 2021Article
- Decreased Incidence of Hepatic Artery Thrombosis in Pediatric Liver Transplantation Using Technical Variant Grafts: Report of the Society of Pediatric Liver Transplantation Experience.The Journal of pediatrics · 2020Article
- Evidence for a rebalanced hemostatic system in pediatric liver transplantation: A prospective cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Graft Loss Due to Thrombosis of an Aortic Conduit in a Pediatric Multivisceral Transplant Recipient.Transplantation direct · 2018Article
- Thrombosis prophylaxis in pediatric liver transplantation: A systematic review.World journal of hepatology · 2018Article
- The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPediatric patients undergoing liver transplant are at significant risk for bleeding and thrombotic complications due to the complex nature of rebalanced hemostasis in patients with liver disease. METHODS/
objectivesWe reviewed records of 92 pediatric liver and multivisceral transplant cases at Duke University Medical Center between January 2009 and December 2015. The goal was to define the nature and incidence of bleeding and thrombotic complications in this cohort and define potential risk factors.
resultsThere were 24 major bleeding events in 19 transplants (incidence 20.7%) and 30 thrombotic events in 23 transplants (incidence 25%). Five of the 10 retransplantations were for vascular thrombotic complications. Thirty-day mortality was 4.9%, and three of these four deaths were due to vascular thrombosis. No bleeding events led to retransplantation or mortality. Prophylactic aspirin was associated with decreased risk of thrombosis without increased bleeding. Prophylactic heparin did not increase bleeding risk. Laboratory assays predicted events poorly, apparently failing to capture the nuanced and dynamic interplay between pro- and anticoagulant factors in the posttransplant patient.
conclusionsBoth bleeding and thrombosis are frequent in this population, but only thrombotic complications contributed to retransplantation and mortality. A standardized approach to coagulation testing and antithrombotic therapy may be useful in predicting and reducing adverse outcomes. Alternative approaches to monitoring hemostasis need to be prospectively investigated in this complex patient population.
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