Evidence map›Paper›PMID 29350324›Full record

ReviewCurrent heart failure reports2018

Evolving Landscape of Clinical Trials in Heart Failure: Patient Populations, Endpoint Selection, and Regions of Enrollment.

Ayman Samman Tahhan, Muthiah Vaduganathan, Stephen J Greene, Maureen Okafor, Sonali Kumar, Javed Butler

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current heart failure reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayman Samman TahhanEmory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
Muthiah VaduganathanBrigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA, USA.
Stephen J GreeneDuke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
Maureen OkaforDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Sonali KumarDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Javed ButlerDivision of Cardiology, Health Sciences Center, Stony Brook University, T-16, Room 080, SUNY, Stony Brook, NY, 11794, USA. javed.butler@stonybrookmedicine.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewClinical trial design and execution are evolving as increasingly important considerations with respect to the success of heart failure trials. The current review highlights temporal trends in characteristics of heart failure clinical trials. RECENT

findingsRecent trials in heart failure have required longer recruitment phases, displayed inefficient enrollment rates, increased use of composite and nonfatal endpoints, undergone rapid globalization, and gradually increased focus on heart failure with preserved ejection fraction. Understanding patterns and trends in clinical trial design and execution may inform future planning and conduct of trials of heart failure therapeutics.

Indexed as

Patient SelectionClinical Trials as TopicEndpoint DeterminationHeart FailureHumansStroke VolumeClinical trialsEndpointsEnrollmentHeart failureTemporal trends

Identifiers

PMID29350324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.