SynthesisJournal of assisted reproduction and genetics2018
Revisiting embryo assisted hatching approaches: a systematic review of the current protocols.
Synthesis in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03623659 (Does Partial Zona Pellucida Removal From Vitrified-warmed Human Blastocysts Improve Delivery Rate in IVF? A Multicentric RCT on Laser Assisted Hatching), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Partial Zona Pellucida Removal From Vitrified-warmed Human Blastocysts Improve Delivery Rate in IVF? A Multicentric RCT on Laser Assisted Hatching
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Two laser-assisted hatching methods of embryos in ART: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Assisted Hatching in Couples with Advanced Maternal Age: A Systematic Review and Meta-analysis.Current medical science · 2018Pooled it
- Zona Pellucida Thickness, Reproductive Aging, and Oocyte Competence in Women with Diminished Ovarian Reserve Undergoing ICSI.Biomedicines · 2026Article
- The effect of laser-assisted hatching on clinical outcomes of frozen-thawed embryo transfer at different embryo ages.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Association between laser-assisted hatching and subsequent blastocyst development in fresh day 3 cleavage-stage embryos: a retrospective cohort study using propensity score matching, generalized estimating equations, and time-sensitivity analyses.Frontiers in endocrinology · 2026Article
- Effect of assisted hatching on pregnancy outcomes following 1,678,872 single embryo transfers based on the Japan Assisted Reproductive Technology Registry.Scientific reports · 2025Article
- Zona-free blastocyst transfers have significantly lower pregnancy and live birth rates compared to zona-intact blastocysts.Journal of assisted reproduction and genetics · 2025Article
- Clinical pregnancy rates after two different methods of laser-assisted hatching applied to vitrified-warmed day-3 embryos or day-5 blastocysts.Clinical and experimental reproductive medicine · 2025Article
- Association between hatching status and pregnancy outcomes in single blastocyst transfers: a retrospective cohort analysis.Journal of assisted reproduction and genetics · 2025Article
- Hyperelastic models for the human zona pellucida and their implications on shear modulus estimation in the clinical practice.Scientific reports · 2024Article
- Nuclear transfer leads to aberrant cell cycle regulation and translation, as determined by gene expression, and selection of mitochondrial DNA in porcine blastocysts.NAR molecular medicine · 2024Article
- Unlocking the Potential of Assisted Hatching in Assisted Reproductive Technology: A Narrative Review.Cureus · 2024Review
- Laser-assisted hatching improves pregnancy outcomes in frozen-thawed embryo transfer cycles of cleavage-stage embryos: a large retrospective cohort study with propensity score matching.Journal of assisted reproduction and genetics · 2023Article
- Lab partners: oocytes, embryos and company. A personal view on aspects of oocyte maturation and the development of monozygotic twins.Animal reproduction · 2023Article
- The Current Practice of Assisted Hatching for Embryos in Fertility Centres: a General Survey.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Laser-assisted hatching zona thinning does not improve the pregnancy outcomes of poor-quality blastocysts in frozen-thawed embryo transfer cycle: a retrospective cohort study.Lasers in medical science · 2022Article
- A comparison of the clinical effects of thinning and drilling on laser-assisted hatching.Lasers in medical science · 2022Review
- From Zygote to Blastocyst: Application of Ultrashort Lasers in the Field of Assisted Reproduction and Developmental Biology.Diagnostics (Basel, Switzerland) · 2021Review
- Trend of medically induced monozygotic twin deliveries according to age, parity, and type of assisted reproductive technique during the period 2007-2017 in Lombardy Region, Northern Italy: a population-based study.Journal of assisted reproduction and genetics · 2021Article
- Laser-assisted hatching on clinical and neonatal outcomes in patients undergoing single vitrified Blastocyst transfer: A propensity score-matched study.Reproductive medicine and biology · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zona pellucida (ZP) manipulation, termed "assisted hatching" (AH), has been introduced in order to favor embryo hatching and ultimately improve assisted reproductive technology success but with poor proofs of safety and biological plausibility. We herein provide a systematic review of clinical outcomes following the application of different methods of ZP manipulation on fresh or frozen/thawed embryos at different developmental stages in different groups of patients. Out of the 69 papers that compared the clinical outcomes deriving from hatched versus non-hatched embryos, only 11 considered blastocysts while the rest referred to cleavage stage embryos. The ZP thinning of fresh embryos either by chemical or laser approach was shown to provide very limited benefit in terms of clinical outcomes. Better results were observed with procedures implying a higher degree of zona manipulation, including zona removal. Studies comparing the mechanical or chemical procedures to those laser-mediated consistently reported a superiority of the latter ones over the former. Literature is consistent for a benefit of ZP breaching in thawed blastocysts. This review provides the current knowledge on the AH procedure in order to improve its efficacy in the appropriate context. Embryologists might benefit from the approaches presented herein in order to improve Assisted Reproduction Technologies (ART) outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.