ArticleJournal of industrial microbiology & biotechnology2018
Immobilization of Methylosinus trichosporium OB3b for methanol production.
Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 32 citations in OpenAlex.
- The role of biological nitrogen fixation in polyhydroxybutyrate production from methane by methane-oxidizing bacteria: a review of metabolic routes and yield enhancement.Frontiers in microbiology · 2025Review
- Methane biohydroxylation into methanol byFrontiers in bioengineering and biotechnology · 2024Article
- Recent advances in methanol production from methanotrophs.World journal of microbiology & biotechnology · 2023Review
- Article
- A novel inverse membrane bioreactor for efficient bioconversion from methane gas to liquid methanol using a microbial gas-phase reaction.Biotechnology for biofuels and bioproducts · 2023Article
- Biomethanol Production from Methane by Immobilized Co-cultures of Methanotrophs.Indian journal of microbiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Due to the natural gas boom in North America, there is renewed interest in the production of other chemical products from methane. We investigated the feasibility of immobilizing the obligate methanotrophic bacterium Methylosinus trichosporium OB3b in alginate beads, and selectively inactivating methanol dehydrogenase (MDH) with cyclopropane to produce methanol. In batch cultures and in semi-continuous flow columns, the exposure of alginate-immobilized cells to cyclopropane or cyclopropanol resulted in the loss of the majority of MDH activity (> 80%), allowing methanol to accumulate to significant concentrations while retaining all of M. trichosporium OB3b's methane monooxygenase capacity. Thereafter, the efficiency of methanol production fell due to recovery of most of the MDH activity; however, subsequent inhibition periods resulted in renewed methanol production efficiency, and immobilized cells retained methane-oxidizing activity for at least 14 days.
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Registered trials
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