Trial reportEuropean journal of applied physiology2018
Lower body blood flow restriction training may induce remote muscle strength adaptations in an active unrestricted arm.
Trial report in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effects of blood flow restriction training on patients with chronic ankle instability: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Comparing adaptations from blood flow restriction exercise training using regulated or unregulated pressure systems: A systematic review and meta-analysis.Clinical rehabilitation · 2024Pooled it
- Is There a Minimum Effective Dose for Vascular Occlusion During Blood Flow Restriction Training?Frontiers in physiology · 2022Pooled it
- The effect of blood flow restriction training on core muscle strength and pain in male collegiate athletes with chronic non-specific low back pain.Frontiers in public health · 2024Trial
- Trial
- Blood Flow Restriction in Athletic Populations-Part 2: Applications in Resistance Training Across the Loading Spectrum.Journal of functional morphology and kinesiology · 2026Review
- How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review.Sports medicine - open · 2025Review
- The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?Frontiers in physiology · 2025Review
- A comparison of blood flow restriction devices to assess limb occlusion pressure in supine and standing positions.Frontiers in sports and active living · 2025Article
- Blood flow restriction-enhanced platelet-rich plasma: A pilot randomised controlled trial protocol.Journal of experimental orthopaedics · 2025Article
- Vertical Strength Transfer Phenomenon Between Upper Body and Lower Body Exercise: Systematic Scoping Review.Sports medicine (Auckland, N.Z.) · 2024Article
- Blood flow restriction augments the cross-education effect of isometric handgrip training.European journal of applied physiology · 2024Article
- Does Beta-Alanine Supplementation Potentiate Muscle Performance Following 6 Weeks of Blood Flow Restriction or Traditional Resistance Training?International journal of exercise science · 2023Article
- Effect of supervised rehabilitation combined with blood flow restriction training in athletes with chronic ankle instability: a randomized placebo-controlled trial.Journal of exercise rehabilitation · 2022Article
- Effects of Training with Blood Flow Restriction on Muscular Strength: A Systematic Review and Meta-Analysis.International journal of exercise science · 2022Review
- Muscle Adaptations to Heavy-Load and Blood Flow Restriction Resistance Training Methods.Frontiers in physiology · 2022Article
- The Systemic Effects of Blood Flow Restriction Training: A Systematic Review.International journal of sports physical therapy · 2021Article
- Effects of Different Types of Lower Body Resistance Exercise on Upper-body Strength in Men and Women, with Special Reference to Anabolic Hormones.International journal of exercise science · 2021Article
- EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON HANDGRIP STRENGTH AND MUSCULAR VOLUME OF YOUNG WOMEN.International journal of sports physical therapy · 2020Article
- Physiological responses of human skeletal muscle to acute blood flow restricted exercise assessed by multimodal MRI.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe examined the concurrent characteristics of the remote development of strength and cross-sectional area (CSA) of upper body skeletal muscle in response to lower body resistance training performed with an applied blood flow restriction (BFR).
methodsMales allocated to an experimental BFR group (EXP; n = 12) or a non-BFR control group (CON; n = 12) completed 7-weeks of resistance training comprising three sets of unilateral bicep curls [50% 1-repetition maximum (1-RM)], then four sets of bilateral knee extension and flexion exercises (30% 1-RM). EXP performed leg exercises with an applied BFR (60% limb occlusion pressure). 1-RM strength was measured using bilateral leg exercises and unilateral bicep curls in both trained and untrained arms. Muscle CSA was measured via peripheral quantitative computed tomography in the dominant leg and both arms.
results1-RM in the trained arm increased more in EXP (2.5 ± 0.4 kg; mean ± SEM) than the contralateral untrained arm (0.8 ± 0.4 kg), and the trained arm of CON (0.6 ± 0.3 kg, P < 0.05). The increase in knee extension 1-RM was twofold that of CON (P < 0.01). Knee flexion 1-RM, leg CSA, and trained arm CSA increased similarly between groups (P > 0.05), while untrained arm CSA did not change (P > 0.05).
conclusionLower limb BFR training increased trained arm strength more than the contralateral untrained arm, and the trained arm of controls. However, there was no additional effect on muscle CSA. These findings support evidence for a BFR training-derived remote strength transfer that may be relevant to populations with localised movement disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.