ArticleEmerging infectious diseases2018
New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 93 citations in OpenAlex.
- Molecular prevalence of equine parvovirus hepatitis in healthy horses from the Northern region of the state of Rio Grande do Sul, Brazil.Veterinary research communications · 2026Article
- Chronic hepatitis in horses with persistent equine hepacivirus infection.Equine veterinary journal · 2026Article
- First Detection and Phylogenetic Analysis of Equine Hepacivirus (EqHV) in Iran.Veterinary medicine and science · 2026Article
- Identification of a novelFrontiers in veterinary science · 2026Article
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- Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin.Veterinary medicine and science · 2025Article
- Breaking new ground: first report of integrating clinical, hematobiochemical, sonographic, and pathological findings in dromedary camels (Frontiers in veterinary science · 2025Article
- Assessment of health impacts in retired antisera-producing horses: Blood biochemistry and serum amyloid A analysis.Veterinary world · 2024Article
- Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia.Viruses · 2024Article
- Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses.Veterinary pathology · 2024Article
- Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Old and Novel Enteric Parvoviruses of Dogs.Pathogens (Basel, Switzerland) · 2023Review
- Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks.Virology journal · 2022Article
- Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022Article
- Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update.Animals : an open access journal from MDPI · 2022Review
- Blood Transfusion in Equids-A Practical Approach and Review.Animals : an open access journal from MDPI · 2022Review
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- Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.Equine veterinary journal · 2022Article
- Viral Safety Issues in the Production and Manufacturing of Human Immunoglobulin Preparations from Equine Plasma/Serum.Pharmaceutical chemistry journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.