ArticleEmerging infectious diseases2018
Yersinia pestis Survival and Replication in Potential Ameba Reservoir.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- CanMicroorganisms · 2023Article
- Article
- Plague and Trace Metals in Natural Systems.International journal of environmental research and public health · 2022Review
- Plague risk in the western United States over seven decades of environmental change.Global change biology · 2022Article
- Exploring and Mitigating Plague for One Health Purposes.Current tropical medicine reports · 2022Article
- No evidence for enzootic plague within black-tailed prairie dog (Cynomys ludovicianus) populations.Integrative zoology · 2021Article
- The roles of environmental variation and parasite survival in virulence-transmission relationships.Royal Society open science · 2021Review
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Human plague: An old scourge that needs new answers.PLoS neglected tropical diseases · 2020Review
- Busting biofilms: free-living amoebae disrupt preformed methicillin-resistantMicrobiology (Reading, England) · 2020Article
- Development of a rapid viability polymerase chain reaction method for detection of Yersinia pestis.Journal of microbiological methods · 2019Article
- Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics.Genes and immunity · 2019Review
- Prairie Dogs, Persistent Plague, Flocking Fleas, and Pernicious Positive Feedback.Frontiers in veterinary science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plague ecology is characterized by sporadic epizootics, then periods of dormancy. Building evidence suggests environmentally ubiquitous amebae act as feral macrophages and hosts to many intracellular pathogens. We conducted environmental genetic surveys and laboratory co-culture infection experiments to assess whether plague bacteria were resistant to digestion by 5 environmental ameba species. First, we demonstrated that Yersinia pestis is resistant or transiently resistant to various ameba species. Second, we showed that Y. pestis survives and replicates intracellularly within Dictyostelium discoideum amebae for ˃48 hours postinfection, whereas control bacteria were destroyed in <1 hour. Finally, we found that Y. pestis resides within ameba structures synonymous with those found in infected human macrophages, for which Y. pestis is a competent pathogen. Evidence supporting amebae as potential plague reservoirs stresses the importance of recognizing pathogen-harboring amebae as threats to public health, agriculture, conservation, and biodefense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.