ArticleEmerging infectious diseases2018
Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012-2014.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
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- Hospital-acquired pneumonia caused by multidrug-resistant Streptococcus pneumoniae serotype 15A.Infection · 2026Article
- Serotype distribution and antimicrobial resistance ofJournal of medical microbiology · 2025Article
- Emergence of a piliated and multidrug-resistantMicrobiology spectrum · 2025Article
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- Nanomedicine approaches to enhance the effectiveness of meropenem: a strategy to tackle antimicrobial resistance.Discover nano · 2025Review
- Invasive pneumococcal diseases in Chinese children: a multicentre hospital-based active surveillance from 2019 to 2021.Emerging microbes & infections · 2024Article
- A global genomic perspective on the multidrug-resistantMicrobial genomics · 2023Article
- Serotypes and Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2023Article
- Frequent Transmission of Streptococcus pneumoniae Serotype 35B and 35D, Clonal Complex 558 Lineage, across Continents and the Formation of Multiple Clades in Japan.Antimicrobial agents and chemotherapy · 2023Article
- Whole-Genome Analysis-Based Phylogeographic Investigation of Streptococcus pneumoniae Serotype 19A Sequence Type 320 Isolates in Japan.Antimicrobial agents and chemotherapy · 2022Article
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- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020).Journal of intensive care · 2021Article
- Antibiotic Resistance and Molecular Biological Characteristics of Non-13-Valent-Pneumococcal Conjugate Vaccine Serogroup 15Frontiers in microbiology · 2021Article
- Article
- Emergence of Meropenem Resistance Among Cefotaxime Non-susceptibleFrontiers in microbiology · 2021Article
- Point-of-care cerebrospinal fluid Gram stain for the management of acute meningitis in adults: a retrospective observational study.Annals of clinical microbiology and antimicrobials · 2020Observational
- Streptococcus pneumoniae Serotype 12F-CC4846 and Invasive Pneumococcal Disease after Introduction of 13-Valent Pneumococcal Conjugate Vaccine, Japan, 2015-2017.Emerging infectious diseases · 2020Article
- Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae SpainEmerging infectious diseases · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the introduction of pneumococcal conjugate vaccines, the incidence of pneumococcal infections due to meropenem-resistant serotype 15A-ST63 strains increased in Japan. By using whole-genome sequencing and comparing sequences with those of clones from the United Kingdom, the United States, and Canada, we clarified the traits of the serotype 15A-ST63 clone. Our analysis revealed that the meropenem-resistant serotype 15A-ST63 strains from Japan originated from meropenem-susceptible strains from Japan. Recombination site prediction analysis showed that the meropenem-resistant strain-specific recombination regions included the pbp1a and pbp2b regions. A detailed analysis of the composition of these genes indicated that resistance seems to be caused by pbp1a recombination. The pbp1a gene in meropenem-resistant isolates was identical to that in multidrug (including meropenem)-resistant serotype 19A-ST320 pneumococci, which have spread in the United States. The global spread of pneumococci of this lineage is noteworthy because serotype 15A is not included in the currently used 13-valent pneumococcal conjugate vaccine.
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