Evidence map›Paper›PMID 29350061›Full record

ReviewAntioxidants & redox signaling2018

The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk.

Thomas Münzel, Mette Sørensen, Frank Schmidt, Erwin Schmidt, Sebastian Steven, Swenja Kröller-Schön, Andreas Daiber

Open access · hybridAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 5 pooled it
43.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 5 syntheses or guidelines pooled it, 265 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Review
  11. Hearing Protection Among Workers Exposed to Occupational Noise in the South African Aluminium Industry.International journal of environmental research and public health · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Observational
  18. Impact of Residential Noise Exposure on Neurological Health: A Systematic Scoping Review.Journal of urban health : bulletin of the New York Academy of Medicine · 2025
    Article
  19. Article
  20. Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thomas Münzel1 The Center for Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center , Mainz, Germany .
Mette Sørensen2 Danish Cancer Society Research Center , Copenhagen, Denmark .
Frank Schmidt1 The Center for Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center , Mainz, Germany .
Erwin Schmidt3 Institute for Molecular Genetics, Johannes Gutenberg University , Mainz, Germany .
Sebastian Steven1 The Center for Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center , Mainz, Germany .
Swenja Kröller-Schön1 The Center for Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center , Mainz, Germany .
Andreas Daiber1 The Center for Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center , Mainz, Germany .
Danish Cancer Society · DKJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological studies have provided evidence that traffic noise exposure is linked to cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke. Noise is a nonspecific stressor that activates the autonomous nervous system and endocrine signaling. According to the noise reaction model introduced by Babisch and colleagues, chronic low levels of noise can cause so-called nonauditory effects, such as disturbances of activity, sleep, and communication, which can trigger a number of emotional responses, including annoyance and subsequent stress. Chronic stress in turn is associated with cardiovascular risk factors, comprising increased blood pressure and dyslipidemia, increased blood viscosity and blood glucose, and activation of blood clotting factors, in animal models and humans. Persistent chronic noise exposure increases the risk of cardiometabolic diseases, including arterial hypertension, coronary artery disease, diabetes mellitus type 2, and stroke. Recently, we demonstrated that aircraft noise exposure during nighttime can induce endothelial dysfunction in healthy subjects and is even more pronounced in coronary artery disease patients. Importantly, impaired endothelial function was ameliorated by acute oral treatment with the antioxidant vitamin C, suggesting that excessive production of reactive oxygen species contributes to this phenomenon. More recently, we introduced a novel animal model of aircraft noise exposure characterizing the underlying molecular mechanisms leading to noise-dependent adverse oxidative stress-related effects on the vasculature. With the present review, we want to provide an overview of epidemiological, translational clinical, and preclinical noise research addressing the nonauditory, adverse effects of noise exposure with focus on oxidative stress. Antioxid. Redox Signal. 28, 873-908.

Indexed as

Oxidative StressCardiovascular DiseasesEnvironmental ExposureEnvironmental PollutantsHumansHypertensionNoiseReactive Oxygen SpeciesRisk FactorsStrokeEnvironmental PollutantsReactive Oxygen Speciesaircraft noise exposureendothelial dysfunctionenvironmental risk factorsoxidative stressstress hormonestraffic noise exposure

Identifiers

PMID29350061
PMCPMC5898791
OpenAlexW2782614909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.