Evidence map›Paper›PMID 29349935›Full record

ArticleJournal of cachexia, sarcopenia and muscle2018

Pitfalls in the measurement of muscle mass: a need for a reference standard.

Fanny Buckinx, Francesco Landi, Matteo Cesari, Roger A Fielding, Marjolein Visser, Klaus Engelke, Stefania Maggi, Elaine Dennison, Nasser M Al-Daghri, Sophie Allepaerts and 21 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 424 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
424citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04584944 unknown statusnot on this mapstarted 2020, after this paper: background citation

Appendicular Skeletal Muscle Mass Adult Reference Measurements in Greek Population

Typeobservational_patient_registrySponsorHenry Dunant Hospital CenterRan2020 to 2022Enrolled500ConditionsPublic Health, SarcopeniaArmsDual energy X-ray absorptiometry
NCT05783700 unknown statusnot on this mapstarted 2023, after this paper: background citation

Identification of Biomarkers for the Study of Sarcopenia and Its Evolution in Diabetic Patients.

TypeobservationalSponsorEsther SolerRan2023 to 2024Enrolled300ConditionsDiabetes Mellitus, Diabetic Foot, Sarcopenia, Neuropathy, DiabeticArmsBIOIMPEDANCEMETRY
3 · Its place in the literature

Who cites it

424 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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364 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Fanny BuckinxDepartment of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Francesco LandiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Milan, Italy.
Matteo CesariGérontopôle, University Hospital of Toulouse, Toulouse, France.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, USA.
Marjolein VisserDepartment of Health Sciences, VU University Amsterdam, Amsterdam, Netherlands.
Klaus EngelkeInstitute of Medical Physics, University of Erlangen, Erlangen, Germany.
Stefania MaggiNational Research Council, Neuroscience Institute, Aging Branch, Padova, Italy.
Elaine DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK.
Nasser M Al-DaghriPrince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Sophie AllepaertsDepartment of Geriatrics, CHU-Liège, Liège, Belgium.
Jurgen BauerDepartment of Geriatric Medicine, Klinikum, Carl von Ossietzky University, Oldenburg, Germany.
Ivan BautmansGerontology and Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Maria Luisa BrandiDepartment of Surgery and Translational Medicine, University of Florence, viale Pieraccini 6, 59139, Florence, Italy.
Olivier BruyèreDepartment of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Tommy CederholmHuman Medicines Research and Development Support Division, Scientific Advice, London, UK.
Francesca CerretaHuman Medicines Research and Development Support Division, Scientific Advice, London, UK.
Antonio CherubiniGeriatrics and Geriatric Emergency Care, IRCCS-INRCA, Ancona, Italy.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK.
Alphonso Cruz-JentoftHospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), Madrid, Spain.
Eugene McCloskeyCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
Bess Dawson-HughesJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Jean-Marc KaufmanDepartment of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium.
Andrea LaslopScientific Office, Austrian Agency for Health and Food Safety, Vienna, Austria.
Jean PetermansDepartment of Geriatrics, CHU-Liège, Liège, Belgium.
Jean-Yves ReginsterDepartment of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
René RizzoliService of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Sian RobinsonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, England, UK.
Yves RollandGérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse); UMR INSERM 1027, University of Toulouse III, Toulouse, France.
Ricardo RuedaAbbott Nutrition R&D, Granada, Spain.
Bruno VellasGérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse); UMR INSERM 1027, University of Toulouse III, Toulouse, France.
John A KanisCentre for Metabolic Bone Diseases, University of Sheffield, UK and Institute of Health and Ageing, Australian Catholic University, Melbourne, Australia.

Funding

Medical Research Council G0400491Medical Research Council MC_U147574218Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

backgroundAll proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard.

methodsLiterature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia. Face-to-face meetings were organized for the whole group to make amendments and discuss further recommendations.

resultsA wide range of techniques can be used to assess muscle mass. Cost, availability, and ease of use can determine whether the techniques are better suited to clinical practice or are more useful for research. No one technique subserves all requirements but dual energy X-ray absorptiometry could be considered as a reference standard (but not a gold standard) for measuring muscle lean body mass.

conclusionsBased on the feasibility, accuracy, safety, and low cost, dual energy X-ray absorptiometry can be considered as the reference standard for measuring muscle mass.

Indexed as

Reference StandardsBone DensityHumansSarcopeniaLean body massLean massMuscle massReference standard

Identifiers

PMID29349935
PMCPMC5879987

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.