Evidence map›Paper›PMID 29349902›Full record

ArticleJournal of cachexia, sarcopenia and muscle2018

Association between pre-sarcopenia, sarcopenia, and bone mineral density in patients with chronic hepatitis C.

Tatiana Bering, Kiara G D Diniz, Marta Paula P Coelho, Diego A Vieira, Maria Marta S Soares, Adriana M Kakehasi, Maria Isabel T D Correia, Rosângela Teixeira, Dulciene M M Queiroz, Gifone A Rocha and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 71 citations in OpenAlex.

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  20. Metabolic complications of hepatitis C virus infection.World journal of gastroenterology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tatiana BeringOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Kiara G D DinizOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Marta Paula P CoelhoOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Diego A VieiraOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Maria Marta S SoaresDepartment of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Adriana M KakehasiLocomotor System Department, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Maria Isabel T D CorreiaDepartment of Surgery, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Rosângela TeixeiraOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Dulciene M M QueirozLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Gifone A RochaLaboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Luciana D SilvaOutpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190 s/216, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreserved skeletal muscle is essential for the maintenance of healthy bone. Loss of bone mineral density (BMD) and muscle strength, considered a predictor of BMD, have been demonstrated in patients with cirrhosis, but they are poorly studied in chronic hepatitis C (CHC) without cirrhosis. Thus, we aimed to evaluate the prevalence of low BMD and its association with body composition, muscle strength, and nutritional status in CHC.

methodsOne hundred and four subjects [mean age, 50.5 ± 11.3 years; 75.0% males; 67.3% non-cirrhotic; and 32.7% with compensated cirrhosis] with CHC, prospectively, underwent scanning of the lean tissue, appendicular skeletal muscle mass (ASM), fat mass, lumbar spine, hip, femoral neck, and whole-body BMD by dual-energy X-ray absorptiometry. Muscle strength was assessed by dynamometry. Sarcopenia was defined by the presence of both low, ASM/height

resultsLow BMD, low muscle strength, pre-sarcopenia, sarcopenia, and sarcopenic obesity were observed in 34.6% (36/104), 27.9% (29/104), 14.4% (15/104), 8.7% (9/104), and 3.8% (4/104) of the patients, respectively. ASMI was an independent predictor of BMD (P < 0.001). Sarcopenia was independently associated with bone mineral content (P = 0.02) and malnutrition (P = 0.01). In 88.9% of the sarcopenic patients and in all with sarcopenic obesity, BMI was normal. The mid-arm muscle circumference was positively correlated with ASMI (r = 0.88; P < 0.001).

conclusionsThis is the first study to demonstrate that ASM is an independent predictor of BMD in CHC. Mid-arm muscle circumference coupled with handgrip strength testing should be incorporated into routine clinical practice to detect low muscle mass, which may be underdiagnosed when only BMI is used. These findings may influence clinical decision-making and contribute to the development of effective strategies to screen the musculoskeletal abnormalities in CHC patients, independently of the stage of the liver disease.

Indexed as

AdultAgedBone DensityCross-Sectional StudiesFemaleHepatitis C, ChronicHumansMaleMiddle AgedSarcopeniaYoung AdultAppendicular skeletal muscle massBone mineral densityChronic hepatitis CSarcopenia

Identifiers

PMID29349902
PMCPMC5879980
OpenAlexW2791824094

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.