Evidence map›Paper›PMID 29349712›Full record

Trial reportBreast cancer research and treatment2018

Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial.

Sara Mijwel, Malin Backman, Kate A Bolam, Emil Olofsson, Jessica Norrbom, Jonas Bergh, Carl Johan Sundberg, Yvonne Wengström, Helene Rundqvist

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06522971 (Exploration of the Molecular Mechanisms Behind the Effects of Physical Exercise on Response to Neoadjuvant Chemotherapy in Breast Cancer Patients), which is not on this map. Cited by 78 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06522971 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Exploration of the Molecular Mechanisms Behind the Effects of Physical Exercise on Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

TypeinterventionalSponsorLatvian Biomedical Research and Study CentreRan2022 to 2027Enrolled55ConditionsBreast CancerArmsHigh-intensiy interval training
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  6. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  8. Efficacy of resistance training during adjuvant chemotherapy and radiation therapy in cancer care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  9. Virtual Reality as a Promising Tool Supporting Oncological Treatment in Breast Cancer.International journal of environmental research and public health · 2021
    Pooled it
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  12. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
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  20. Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sara MijwelDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. sara.mijwel@ki.se.ORCID http://orcid.org/0000-0002-6718-5797
Malin BackmanDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Kate A BolamDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Emil OlofssonDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Jessica NorrbomDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Jonas BerghDepartment of Oncology and Pathology Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
Carl Johan SundbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Yvonne WengströmDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Helene RundqvistDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Funding

Cancerfonden 130452Cancerföreningen i Stockholm 131242Svenska Cancer och Trafikskadades Riksförbund F-C-001225Svenska Läkaresällskapet SLS 50514
6 · The paper itself

Abstract

backgroundAdvanced therapeutic strategies are often accompanied by significant adverse effects, which warrant equally progressive countermeasures. Physical exercise has proven an effective intervention to improve physical function and reduce fatigue in patients undergoing chemotherapy. Effects of high-intensity interval training (HIIT) in this population are not well established although HIIT has proven effective in other clinical populations. The aim of the OptiTrain trial was to examine the effects of concurrent resistance and high-intensity interval training (RT-HIIT) or concurrent moderate-intensity aerobic and high-intensity interval training (AT-HIIT), to usual care (UC) on pain sensitivity and physiological outcomes in patients with breast cancer during chemotherapy.

methodsTwo hundred and forty women were randomized to 16 weeks of RT-HIIT, AT-HIIT, or UC. OUTCOMES: cardiorespiratory fitness, muscle strength, body mass, hemoglobin levels, and pressure-pain threshold.

resultsPre- to post-intervention, RT-HIIT (ES = 0.41) and AT-HIIT (ES = 0.42) prevented the reduced cardiorespiratory fitness found with UC. Handgrip strength (surgery side: RT-HIIT vs. UC: ES = 0.41, RT-HIIT vs. AT-HIIT: ES = 0.28; non-surgery side: RT-HIIT vs. UC: ES = 0.35, RT-HIIT vs. AT-HIIT: ES = 0.22) and lower-limb muscle strength (RT-HIIT vs. UC: ES = 0.66, RT-HIIT vs. AT-HIIT: ES = 0.23) were significantly improved in the RT-HIIT. Increases in body mass were smaller in RT-HIIT (ES = - 0.16) and AT-HIIT (ES = - 0.16) versus UC. RT-HIIT reported higher pressure-pain thresholds than UC (trapezius: ES = 0.46, gluteus: ES = 0.53) and AT-HIIT (trapezius: ES = 0.30).

conclusionSixteen weeks of RT-HIIT significantly improved muscle strength and reduced pain sensitivity. Both exercise programs were well tolerated and were equally efficient in preventing increases in body mass and in preventing declines in cardiorespiratory fitness. These results highlight the importance of implementing a combination of resistance and high-intensity interval training during chemotherapy for women with breast cancer.

Indexed as

High-Intensity Interval TrainingAdolescentAdultAgedBody CompositionBreast NeoplasmsExerciseFatigueFemaleHand StrengthHumansMiddle AgedMuscle, SkeletalObesityOverweightResistance TrainingBreast cancerChemotherapyHigh-intensity interval trainingPressure-pain threshold

Identifiers

PMID29349712
PMCPMC5882634

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.