ReviewCurrent osteoporosis reports2018
Solute Transport in the Bone Lacunar-Canalicular System (LCS).
Review in Current osteoporosis reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Microgravity-Induced Osteocyte Dysfunction: An Osteocyte Mechanobiology Unit Framework.Current osteoporosis reports · 2026Review
- CFTR mediates ClNature communications · 2026Article
- Rethinking osteocyte modelsFrontiers in bioengineering and biotechnology · 2026Review
- Effect of Solute Molecular Weights on Mass Transfer within the Rat Lacunar-Canalicular System under Gravity.Tissue engineering and regenerative medicine · 2025Article
- Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?Cytoskeleton (Hoboken, N.J.) · 2025Review
- Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025Review
- Effects on Mass Transfer in the Bone Lacunar-Canalicular System under Different Radial Extracorporeal Shock Waves.Tissue engineering and regenerative medicine · 2025Article
- Toward a clear relationship between mechanical signals and bone adaptation.Mechanobiology in medicine · 2025Review
- The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis.International journal of molecular sciences · 2023Review
- Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity.Bone research · 2022Review
- Study on mass transfer in the bone lacunar-canalicular system under different gravity fields.Journal of bone and mineral metabolism · 2022Article
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- Osteosarcopenia: A Narrative Review on Clinical Studies.International journal of molecular sciences · 2022Review
- Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration.Frontiers in cell and developmental biology · 2022Review
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- The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction - A systematic review.Journal of orthopaedic translation · 2021Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
purpose of reviewSolute transport in the lacunar-canalicular system (LCS) plays important roles in osteocyte metabolism and cell-cell signaling. This review will summarize recent studies that establish pericellular matrix (PCM), discovered inside the LCS, as a crucial regulator of solute transport in bone. RECENT
findingsUtilizing confocal imaging and mathematical modeling, recent studies successfully quantified molecular diffusion and convection in the LCS as well as the size-dependent sieving effects of the PCM, leading to the quantification of the effective PCM fiber spacing (10 to 17 nm) in murine adult bones. Perlecan/HSPG2, a large linear proteoglycan, was identified to be an essential PCM component. The PCM-filled LCS is bone's chromatographic column, where fluid/solute transport to and from the osteocytes is regulated. The chemical composition, deposition rate, and turnover rate of the osteocyte PCM should be further defined to better understand osteocyte physiology and bone metabolism.
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Registered trials
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