Evidence map›Paper›PMID 29349663›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2018

Ibandronate metal complexes: solution behavior and antiparasitic activity.

Bruno Demoro, Santiago Rostán, Mauricio Moncada, Zhu-Hong Li, Roberto Docampo, Claudio Olea Azar, Juan Diego Maya, Julia Torres, Dinorah Gambino, Lucía Otero

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Multi-target heteroleptic palladium bisphosphonate complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bruno DemoroQuímica Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800, Montevideo, Uruguay.
Santiago RostánQuímica Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800, Montevideo, Uruguay.
Mauricio MoncadaDepartamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Zhu-Hong LiCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, USA.
Roberto DocampoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, USA.
Claudio Olea AzarDepartamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Juan Diego MayaICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Julia TorresQuímica Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800, Montevideo, Uruguay.
Dinorah GambinoQuímica Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800, Montevideo, Uruguay.
Lucía OteroQuímica Inorgánica, Facultad de Química, Universidad de la República, Gral. Flores 2124, 11800, Montevideo, Uruguay. luotero@fq.edu.uy.

Funding

Pathogenesis of Trypanosoma cruzi infectionR01AI107663 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2014 to 2017
$1.5M
NIAID NIH HHS R01 AI107663
6 · The paper itself

Abstract

To face the high costs of developing new drugs, researchers in both industry and academy are looking for ways to repurpose old drugs for new uses. In this sense, bisphosphonates that are clinically used for bone diseases have been studied as agents against Trypanosoma cruzi, causative parasite of Chagas disease. In this work, the development of first row transition metal complexes (M = Co

Indexed as

Alkyl and Aryl TransferasesAnimalsAntiprotozoal AgentsChlorocebus aethiopsGeranyltranstransferaseIbandronic AcidMetalsTrypanosoma cruziVero CellsAlkyl and Aryl TransferasesAntiprotozoal AgentsGeranyltranstransferaseIbandronic AcidMetalstrans-octaprenyltranstransferaseIbandronate complexesSolution studiesTrypanosoma cruzi

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.