Evidence map›Paper›PMID 29349290›Full record

ArticleeNeuro

A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75

Shayri G Greenwood, Laura Montroull, Marta Volosin, Helen E Scharfman, Kenneth K Teng, Matthew Light, Risa Torkin, Fredrick Maxfield, Barbara L Hempstead, Wilma J Friedman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Nerve growth factor receptor (NGFR): A key player in glioblastoma progression.Biochimica et biophysica acta. Reviews on cancer · 2026
    Review
  2. Review
  3. Review
  4. In vivo functions of p75Trends in pharmacological sciences · 2021
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Shayri G GreenwoodDepartment of Biological Science, Rutgers University, Newark, NJ 07102.ORCID 0000-0001-5482-4484
Laura MontroullDepartment of Biological Science, Rutgers University, Newark, NJ 07102.ORCID 0000-0002-6583-9240
Marta VolosinDepartment of Biological Science, Rutgers University, Newark, NJ 07102.
Helen E ScharfmanNathan Kline Institute, Orangeburg, NY 10962.ORCID 0000-0003-4006-3383
Kenneth K TengDepartment of Medicine, Weill Cornell Medical College, New York, NY.ORCID 0000-0002-9392-2172
Matthew LightDepartment of Medicine, Weill Cornell Medical College, New York, NY.ORCID 0000-0002-2811-7134
Risa TorkinDepartment of Medicine, Weill Cornell Medical College, New York, NY.
Fredrick MaxfieldDepartment of Medicine, Weill Cornell Medical College, New York, NY.ORCID 0000-0003-4396-8866
Barbara L HempsteadDepartment of Medicine, Weill Cornell Medical College, New York, NY.
Wilma J FriedmanDepartment of Biological Science, Rutgers University, Newark, NJ 07102.ORCID 0000-0002-3638-3504
Cornell University · USRutgers, The State University of New Jersey · USNathan Kline Institute for Psychiatric Research · US

Funding

Hyperexcitability in Alzheimer's DiseaseR01AG055328 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2017 to 2021
$2.0M
Modulating ProNGF-induced cell death in Epilepsy: strategies for neuroprotectionR01NS070173 · NINDS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI FRIEDMAN, WILMA J, HEMPSTEAD, BARBARA L · 2011 to 2014
$2.0M
NIA NIH HHS R01 AG055328NINDS NIH HHS R01 NS070173
6 · The paper itself

Abstract

Neurotrophins play critical roles in the survival, maintenance and death of neurons. In particular, proneurotrophins have been shown to mediate cell death following brain injury induced by status epilepticus (SE) in rats. Previous studies have shown that pilocarpine-induced seizures lead to increased levels of proNGF, which binds to the p75

Indexed as

Adaptor Proteins, Vesicular TransportAnimalsCell DeathCells, CulturedCitratesDose-Response Relationship, DrugHippocampusHumansMaleNeuronsNeuroprotective AgentsPilocarpineRatsReceptors, Nerve Growth FactorSf9 CellsSortilinAdaptor Proteins, Vesicular TransportCitrateslithium citrateNeuroprotective AgentsNgfr protein, mousePilocarpineReceptors, Nerve Growth FactorSortilinapoptosisneuroprotectionneurotrophinsp75proNGFseizures

Identifiers

PMID29349290
PMCPMC5771681
OpenAlexW2784103302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.