ArticlePsychiatry journal2017
Self-Reported Adverse Drug Reactions, Medication Adherence, and Clinical Outcomes among Major Depressive Disorder Patients in Ethiopia: A Prospective Hospital Based Study.
Article in Psychiatry journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-adherence level of pharmacotherapy and its predictors among mental disorders in a resource-limited life trajectories: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- What is the impact of antidepressant side effects on medication adherence among adult patients diagnosed with depressive disorder: A systematic review.Journal of psychopharmacology (Oxford, England) · 2024Pooled it
- Factors associated with fluoxetine adherence among outpatients with common mental disorders in Western Kenya.BMJ global health · 2025Trial
- Article
- Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.Annals of general psychiatry · 2026Article
- Psychosocial and clinical determinants of medication adherence among elderly chronic disease patients in China.Frontiers in pharmacology · 2026Article
- Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross-Sectional Study.Depression and anxiety · 2026Article
- Factors Associated With Non-adherence to Anti-depressant Medication in Adults: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Article
- Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal.Depression research and treatment · 2020Article
- Catastrophic health expenditure and impoverishment in households of persons with depression: a cross-sectional, comparative study in rural Ethiopia.BMC public health · 2019Article
- Relationship between treatment and period of absence among employees on sick leave due to mental disease.Industrial health · 2019Article
- Corrigendum to "Self-Reported Adverse Drug Reactions, Medication Adherence, and Clinical Outcomes among Major Depressive Disorder Patients in Ethiopia: A Prospective Hospital Based Study".Psychiatry journal · 2018Article
- An observational study to evaluate the awareness of drug treatment, prescription pattern, adverse drug reactions, and adherence in patients of major depressive disorder.Perspectives in clinical researchArticle
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is paucity of data on prevalence of Adverse Drug Reactions (ADRs) and adherence and clinical outcomes of antidepressants. The present study determined the magnitude of ADRs of antidepressants and their impact on the level of adherence and clinical outcome.
methodsA prospective cross-sectional study was conducted among depression patients from September 2016 to January 2017 at Gondar University Hospital psychiatry clinic. The Naranjo ADR probability scale was employed to assess the ADRs. The rate of medication adherence was determined using Morisky Medication Adherence Measurement Scale-Eight.
resultsTwo hundred seventeen patients participated in the study, more than half of them being males (122; 56.2%). More than one-half of the subjects had low adherence to their medications (124; 57.1%) and about 186 (85.7%) of the patients encountered ADR. The most common ADR was weight gain (29; 13.2%). More than one-half (125; 57.6%) of the respondents showed improved clinical outcome. Optimal level of medication adherence decreased the likelihood of poor clinical outcome by 56.8%.
conclusionADRs were more prevalent. However, adherence to medications was very poor in the setup. Long duration of depression negatively affects the rate of adherence. In addition, adherence was found to influence the clinical outcome of depression patients.
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