Evidence map›Paper›PMID 29349035›Full record

ArticleRespiratory medicine case reports2018

Successful treatment of a patient with chyluria due to lymphangioleiomyomatosis using sirolimus.

Takahiko Sakaue, Masaki Tominaga, Takashi Niizeki, Yoshiaki Zaizen, Ken Matsukuma, Masamichi Koganemaru, Tomoaki Hoshino, Takuji Torimura

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Central Lymphatic Imaging in Adults with Spontaneous Chyluria.International journal of general medicine · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takahiko SakaueDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Masaki TominagaDivision of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University, School of Medicine, Japan.
Takashi NiizekiDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Yoshiaki ZaizenDivision of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University, School of Medicine, Japan.
Ken MatsukumaDepartment of Obstetrics and Gynecology, Kurume University, School of Medicine, Japan.
Masamichi KoganemaruDepartment of Radiology, Department of Medicine, Kurume University, School of Medicine, Japan.
Tomoaki HoshinoDivision of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University, School of Medicine, Japan.
Takuji TorimuraDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Kurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare and progressive neoplastic disease of young woman, characterized by the proliferation of abnormal smooth muscle-like cells (LAM cells) in the lungs and axial lymphatics. A 44-year-old woman was referred to our hospital because pleural effusion was detected during a health checkup. She had chylothorax, chylous ascites, and chyluria, and her computed tomography scan showed a solid tumor in the pelvis. Surgical biopsy was performed; she was diagnosed as having LAM. We could not control the fluid collection and chyluria using standard medical treatments. Therefore, we chose to administer sirolimus, and her symptoms dramatically improved. The mechanism of chyluria presumably involved LAM cell infiltrates in the ureter via the lymphatic vessel flow, which causes LAM to develop because of ureter wall exposure.

Indexed as

ChylothoraxChylous ascitesChyluriaEzetimibeLymphangioleiomyomatosisSirolimus

Identifiers

PMID29349035
PMCPMC5767566
OpenAlexW2781495955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.