Evidence map›Paper›PMID 29348882›Full record

ArticleOncotarget2017

MicroRNA203a suppresses glioma tumorigenesis through an ATM-dependent interferon response pathway.

Chuan He Yang, Yinan Wang, Michelle Sims, Chun Cai, Ping He, Hans Häcker, Junming Yue, Jinjun Cheng, Frederick A Boop, Lawrence M Pfeffer

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Chuan He YangDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Yinan WangDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Michelle SimsDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Chun CaiCenter for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Ping HeCenter for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Hans HäckerDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Junming YueDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jinjun ChengDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Frederick A BoopDepartment of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Lawrence M PfefferDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Center for Cancer Research · USUniversity of Tennessee Health Science Center · USChina Medical University · CNSt. Jude Children's Research Hospital · US

Funding

Strategies to improve the antiglioma action of IFN-?: a role for NF-kB inhibitionR01CA133322 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAVIDOFF, ANDREW M, PFEFFER, LAWRENCE MARC · 2009 to 2013
$2.6M
NCI NIH HHS R01 CA133322
6 · The paper itself

Abstract

Glioblastoma (GBM) is a deadly and incurable brain tumor. Although microRNAs (miRNAs) play critical roles in regulating the cancer cell phenotype, the underlying mechanisms of how they regulate tumorigenesis are incompletely understood. We previously showed that miR-203a is expressed at relatively low levels in GBM patients, and ectopic miR-203a expression in GBM cell lines inhibited cell proliferation and migration, increased sensitivity to apoptosis induced by interferon (IFN) or temozolomide

Indexed as

ATMglioblastomainterferoninterferon signalingmiR-203

Identifiers

PMID29348882
PMCPMC5762567
OpenAlexW2773748583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.