Evidence map›Paper›PMID 29348806›Full record

ArticleACS medicinal chemistry letters2018

Therapeutic Nanosystem Consisting of Singlet-Oxygen-Responsive Prodrug and Photosensitizer Excited by Two-Photon Light.

Yi Lin, Xiao-Fang Jiang, Xiangyan Duan, Fang Zeng, Bo Wu, Shuizhu Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi LinState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
Xiao-Fang JiangState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
Xiangyan DuanState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
Fang ZengState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
Bo WuState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
Shuizhu WuState Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using light as the sole stimulus and employing the generated singlet oxygen as a therapeutic agent and the trigger to activate chemo-drug release could serve as an elegant way to bring into full play the advantageous features of light and enhance therapeutic efficacy through a combination of chemotherapy and photodynamic therapy. Herein a liposomal drug system has been developed by embedding a fluorescent photosensitizer and a prodrug into phospholipid vesicles. Upon one- or two-photon light irradiation, the photosensitizer generates singlet oxygen, which removes the protecting group of the prodrug and subsequently causes the release of the active drug chlorambucil. With the combined action of O

Identifiers

PMID29348806
PMCPMC5767894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.