Evidence map›Paper›PMID 29348798›Full record

ReviewInternational journal of physiology, pathophysiology and pharmacology2017

TRPM7 is a unique target for therapeutic intervention of stroke.

Jun Lin, Zhi-Gang Xiong

Open access · greenAbstract readReview
In one paragraph

Review in International journal of physiology, pathophysiology and pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. TRP Channels in Stroke.Neuroscience bulletin · 2024
    Review
  5. Article
  6. Article
  7. Zinc Homeostasis in Platelet-Related Diseases.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jun LinDepartment of Anesthesiology, Stony Brook University Health Sciences Center, Stony BrookNY 11794-8480, USA.
Zhi-Gang XiongDepartment of Neurobiology, MRC219, Morehouse School of MedicineAtlanta, GA 30310, USA.
Morehouse School of Medicine · USStony Brook Medicine · US

Funding

Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3M
Program Evaluation - Internal & External U54NS083932 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MACLEISH, PETER RAYMOND · 2013 to 2017
$7.7M
ASICs and increased ischemic brain injury in diabetic conditionR01NS066027 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI XIONG, ZHIGANG · 2011 to 2015
$1.6M
NIMHD NIH HHS S21 MD000101NINDS NIH HHS R01 NS066027NINDS NIH HHS U54 NS083932
6 · The paper itself

Abstract

Ischemic stroke is a leading cause of death and long-term disabilities. The current therapy is limited to thrombolysis and mechanical recanalization, which have limited success. A better understanding of the mechanisms underlying ischemic brain injury is therefore needed for the development of more effective interventions. Glutamate receptor-mediated Ca

Indexed as

Ca2+neurotoxicityStrokeTRPM7Zn2+

Identifiers

PMID29348798
PMCPMC5770518
OpenAlexW3023372609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.