ArticleEuropean journal of clinical nutrition2018
Fetal vitamin D concentration and growth, adiposity and neurodevelopment during infancy.
Article in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.Frontiers in neuroscience · 2026Pooled it
- Pooled it
- Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review.Wellcome open research · 2020Pooled it
- High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Trial
- Prenatal sunlight in the second trimester predicts timing of menarche in Polish women born between 1985 and 1991.International journal of biometeorology · 2026Article
- Gestational vitamin D concentration and child cognitive development: a longitudinal cohort study in the Environmental influences on Child Health Outcomes Program.The American journal of clinical nutrition · 2025Article
- Cord blood vitamin A and vitamin D levels in relation to physical growth in exclusively breastfed infants aged 0-6 months.Frontiers in endocrinology · 2024Observational
- "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.Hormones (Athens, Greece) · 2023Review
- Maternal and neonatal blood vitamin D status and neurodevelopment at 24 months of age: a prospective birth cohort study.World journal of pediatrics : WJP · 2023Article
- Greater Gestational Vitamin D Status is Associated with Reduced Childhood Behavioral Problems in the Environmental Influences on Child Health Outcomes Program.The Journal of nutrition · 2023Article
- Correlation between Cord Blood Vitamin D Levels and Problem-Solving Neurodevelopment in Early Childhood: A Cohort Study in Rural Indonesia.Children (Basel, Switzerland) · 2022Article
- Vitamin D Status during Pregnancy versus the Anthropometric Parameters of Two- and Four-Year-Olds: A Pilot Study.Nutrients · 2022Article
- Maternal Plasma 25-Hydroxyvitamin D during Gestation Is Positively Associated with Neurocognitive Development in Offspring at Age 4-6 Years.The Journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo determine the association between cord blood 25-hydroxyvitamin D (25(OH)D) concentration with growth, adiposity and neurodevelopment during infancy. SUBJECTS/
methodsSerum 25(OH)D was measured in cord blood by the liquid chromatography tandem mass spectrometry (LC-MS/MS) from the Shanghai's "Allergy and Obesity Cohort study" (n = 1244). Weight, length, head circumference, and body mass index (BMI) z-scores for age were calculated based on World Health Organization Standard (at 6 months, 1 years, and 2 years). Neurodevelopment was measured at 2 years using Ages and Stages Questionnaire. Generalized estimating equation and multivariable logistic regression model were exploited to examine associations between fetal 25(OH)D concentration and offspring outcomes.
resultsThe median of the 25(OH)D concentration in cord blood was 22.4 ng/ml (interquartile range, 27.3-8.6). Infants born in winter had lower 25(OH)D concentration. 25(OH)D deficiency was not associated with weight z-score (mean difference, 0.07; 95% confidence internal (CI), -0.09 to 0.23), length z-score (mean difference, 0.01; 95% CI, -0.19 to 0.21), head circumference z-score (mean difference, -0.06; 95% CI, -0.27 to 0.15) and BMI z-score (mean difference, 0.09; 95% CI, -0.07 to 0.25) or neurodevelopment during infancy, adjusting for sex, socio-economic position, pre-pregnancy maternal BMI, and maternal and neonatal characteristics. The associations did not vary by gender. A sensitivity analysis of available case analysis showed virtually the same results.
conclusionsFetal vitamin D concentration was not associated with growth, adiposity or neurodevelopment during infancy. The role of vitamin D concentration and its mechanistic pathway in the early origins of adiposity needs to be clarified.
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