Evidence map›Paper›PMID 29348586›Full record

ArticleScientific reports2018

Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition.

Cynthia A Danquah, Eleftheria Kakagianni, Proma Khondkar, Arundhati Maitra, Mukhlesur Rahman, Dimitrios Evangelopoulos, Timothy D McHugh, Paul Stapleton, John Malkinson, Sanjib Bhakta and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. The Phytochemistry and Pharmacology ofMolecules (Basel, Switzerland) · 2022
    Review
  3. Pyridine-N-Oxide Alkaloids fromBioMed research international · 2022
    Article
  4. Article
  5. Investigating GhanaianAntibiotics (Basel, Switzerland) · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cynthia A DanquahResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Eleftheria KakagianniResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Proma KhondkarResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Arundhati MaitraDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, UK.
Mukhlesur RahmanMedicine Research Group, School of Health, Sport and Bioscience, University of East London, Water Lane, London, E15 4LZ, UK.ORCID http://orcid.org/0000-0001-8180-7970
Dimitrios EvangelopoulosCentre for Clinical Microbiology, UCL Royal Free Hospital, Rowland Hill, London, NW3 2PF, UK.
Timothy D McHughCentre for Clinical Microbiology, UCL Royal Free Hospital, Rowland Hill, London, NW3 2PF, UK.ORCID http://orcid.org/0000-0003-4658-8594
Paul StapletonResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
John MalkinsonResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Sanjib BhaktaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, UK. s.bhakta@bbk.ac.uk.ORCID http://orcid.org/0000-0002-1165-9295
Simon GibbonsResearch Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK. simon.gibbons@ucl.ac.uk.

Funding

Medical Research Council G0801956Medical Research Council G0802079Wellcome Trust
6 · The paper itself

Abstract

Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate, exhibited antimicrobial activity, with one compound inhibiting the growth of Mycobacterium tuberculosis at 17 µM (4 mg L

Indexed as

AlliumAntitubercular AgentsBiofilmsDisulfidesEscherichia coliGenes, MDRKlebsiellaMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsProteusStaphylococcus aureusAntitubercular AgentsDisulfidesPlant Extracts

Identifiers

PMID29348586
PMCPMC5773482

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.