ArticleScientific reports2018
Nanostructured titanium surfaces exhibit recalcitrance towards Staphylococcus epidermidis biofilm formation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021Pooled it
- Hierarchical Peptide Functionalized Titania Nanotubes: Improving Stability, Promoting Osteogenesis, and Reducing Infection Risk.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Preparation methods, mechano-bactericidal performance and mechanisms of Ti-based nanostructure arrays: A review.Discover nano · 2026Review
- Effect of High-Energy Excimer Treatment of Ti-Based Alloys on Cytocompatibility and Antibacterial Properties.International journal of molecular sciences · 2026Article
- Synchrotron cryo-soft X-ray microscopy reveals bacterial interactions with nanostructured calcium phosphate substrates.Nature communications · 2026Article
- Balancing Osseointegration and Infection Control: The Role of Titanium Surface Topography in Peri-Implant Biology.Journal of functional biomaterials · 2026Article
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- Evaluation of biological functionality of biomaterial surface modified by advanced laser equipment.Journal of materials science. Materials in medicine · 2025Article
- Long-Term Antibiofilm Efficacy of Slippery Covalently Attached Liquid-like Surfaces in Dynamic and Static Culture Conditions.ACS applied bio materials · 2025Article
- Combined Effects of Dual-Scale Modified Surface with Micro- and Nanostructures on the Cellular Biocompatibility, Osteoinduction, and Antibacterial Properties of Titanium Implants.Journal of functional biomaterials · 2025Article
- In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite.Journal of functional biomaterials · 2025Article
- Application of artificial neural network for the mechano-bactericidal effect of bioinspired nanopatterned surfaces.European biophysics journal : EBJ · 2024Article
- Recent Advances in Antibacterial Strategies Based on TiOBiomimetics (Basel, Switzerland) · 2024Review
- Modern Microbiological Methods to Detect Biofilm Formation in Orthopedy and Suggestions for Antibiotic Therapy, with Particular Emphasis on Prosthetic Joint Infection (PJI).Microorganisms · 2024Review
- Effect of Low-Temperature Oxygen Plasma Treatment of Titanium Alloy Surface on Tannic Acid Coating Deposition.Materials (Basel, Switzerland) · 2024Article
- Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant.International journal of nanomedicine · 2024Review
- Femtosecond laser modified metal surfaces alter biofilm architecture and reduce bacterial biofilm formation.Nanoscale advances · 2023Article
- Designing Effective Antimicrobial Nanostructured Surfaces: Highlighting the Lack of Consensus in the Literature.ACS omega · 2023Review
- Characterization and investigation of electrochemical and biological properties of antibacterial silver nanoparticle-deposited TiOScientific reports · 2023Article
- Biofunctionalization of Porous Titanium Oxide through Amino Acid Coupling for Biomaterial Design.Materials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Titanium-based implants are ubiquitous in the healthcare industries and often suffer from bacterial attachment which results in infections. An innovative method of reducing bacterial growth is to employ nanostructures on implant materials that cause contact-dependent cell death by mechanical rupture of bacterial cell membranes. To achieve this, we synthesized nanostructures with different architectures on titanium surfaces using hydrothermal treatment processes and then examined the growth of Staphylococcus epidermidis on these surfaces. The structure obtained after a two-hour hydrothermal treatment (referred to as spear-type) showed the least bacterial attachment at short times but over a period of 6 days tended to support the formation of thick biofilms. By contrast, the structure obtained after a three-hour hydrothermal treatment (referred to as pocket-type) was found to delay biofilm formation up to 6 days and killed 47% of the initially attached bacteria by penetrating or compressing the bacteria in between the network of intertwined nano-spears. The results point to the efficacy of pocket-type nanostructure in increasing the killing rate of individual bacteria and potentially delaying longer-term biofilm formation.
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Registered trials
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