ArticleScientific reports2018
Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Metabolic Reprogramming and GM-CSF Secretion in Areca Nut-Activated Fibroblasts Drive Oral Precancer Progression.Oral diseases · 2026Article
- Exploring Mechanistic Targets ofInternational journal of molecular sciences · 2026Article
- Molecular mechanisms of therapeutic resistance in areca nut-associated oral squamous cell carcinoma: the interplay of chronic inflammation and epithelial-mesenchymal transition.Frontiers in oncology · 2026Review
- Inflammatory, Immune-Metabolic, and Vascular Biomarker Trajectories Across Treatment Modalities and Associations with Treatment-Related Complications in Oral Squamous Cell Carcinoma: A Prospective Study in Taiwan.Cancer management and research · 2026Article
- Correlation of specific addictions with cancer sites identified among patients in Northeast India.Scientific reports · 2025Article
- Anti-Neuroinflammatory Potential of Areca Nut Extract and Its Bioactive Compounds in Anthracene-Induced BV-2 Microglial Cell Activation.Nutrients · 2024Article
- Betel quid use is associated with anemia among both men and women in Matlab, Bangladesh.PLOS global public health · 2023Article
- Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction.Molecules (Basel, Switzerland) · 2022Review
- Role of TNFSF15 variants in oral cancer development and clinicopathologic characteristics.Journal of cellular and molecular medicine · 2022Article
- Betel Nut Chewing Decreased Calcaneus Ultrasound T-Score in a Large Taiwanese Population Follow-Up Study.Nutrients · 2021Article
- Evaluation of clinical, histological, TNF-α, and collagen expressions on oral ulcer in rats after treatment withF1000Research · 2021Article
- Possible Immunotherapeutic Strategies Based on Carcinogen-Dependent Subgroup Classification for Oral Cancer.Frontiers in molecular biosciences · 2021Review
- Cytotoxic Effects of Betel Quid and Areca Nut Aqueous Extracts on Mouse Fibroblast, Human Mouth-Ordinary-Epithelium 1 and Human Oral Squamous Cell Carcinoma Cell Lines.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Analysis of phenolic compounds and immunomodulatory activity of areca nut extract from Aceh, Indonesia, againstVeterinary world · 2020Article
- Decoding the link associated with areca nut chewing and cardiovascular disease using hsCRP as a biomarker.Journal of oral and maxillofacial pathology : JOMFPArticle
- Peri-implant clinicoradiographic status among betel-quid chewers and controls.Brazilian dental journalObservational
- Molecular effects of areca nut-derived compounds on human oral cancer cells: a systematic review of in vitro evidence.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Betel nut consumption has significant implications for the public health globally, as the wide-spread habit of Areca chewing throughout Asia and the Pacific is associated with a high prevalence of oral carcinoma and other diseases. Despite a clear causal association of betel nut chewing and oral mucosal diseases, the biological mechanisms that link Areca nut-contained molecules, inflammation and cancer remain underexplored. In this study we show that the whole Areca nut extract (ANE) is capable of mobilizing Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.