ArticleNature communications2018
CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05910762 (Learning Novel Structure Across Time and Sleep), which is not on this map. Cited by 111 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Learning Novel Structure Across Time and Sleep
Who cites it
111 citing papers in PubMed.
- Virtual reality video game improves high-fidelity memory in older adults.Scientific reports · 2021Trial
- Hippocampal circuits underlie improvements in self-reported anxiety following mindfulness training.Brain and behavior · 2020Trial
- Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2026Article
- Principal Components Analysis Relates Hippocampal Trisynaptic Circuit to Vividness of Visual Mental Imagery.Brain and behavior · 2026Article
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- MRecover: A Conditional Generative Model for Recovering Motion- Corrupted MR images Using AI Generated Contrast.Research square · 2026Article
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm.Translational psychiatry · 2026Article
- Reduced neural specificity for a romantic partner in the nucleus accumbens over relationship duration.Social cognitive and affective neuroscience · 2026Article
- Neural Patterns Reflect Shared Emotional History.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Age-dependent vulnerability to spatial memory interference in APP/PS1 mice.Frontiers in aging neuroscience · 2026Article
- Hippocampal subfield diffusion abnormalities in Parkinson's disease with mild cognitive impairment: a volumetric and diffusion MRI study.Frontiers in aging neuroscience · 2026Article
- Impaired consolidation of spatial memory during sleep in patients with leucine-rich glioma-inactivated 1-associated limbic encephalitis.Brain communications · 2026Article
- The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.Journal of cognitive neuroscience · 2026Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.bioRxiv : the preprint server for biology · 2025Article
- A Toaster in the Bathroom: Neural Correlates of Semantic Construction During Episodic Memory Recall.Human brain mapping · 2025Article
- Hippocampal transformations occur along dimensions of memory interference.bioRxiv : the preprint server for biology · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- Volumetric alterations of hippocampal and amygdala subfields in Azheimer's disease.BMC medical imaging · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The hippocampus plays a critical role in spatial and episodic memory. Mechanistic models predict that hippocampal subfields have computational specializations that differentially support memory. However, there is little empirical evidence suggesting differences between the subfields, particularly in humans. To clarify how hippocampal subfields support human spatial and episodic memory, we developed a virtual reality paradigm where participants passively navigated through houses (spatial contexts) across a series of videos (episodic contexts). We then used multivariate analyses of high-resolution fMRI data to identify neural representations of contextual information during recollection. Multi-voxel pattern similarity analyses revealed that CA1 represented objects that shared an episodic context as more similar than those from different episodic contexts. CA23DG showed the opposite pattern, differentiating between objects encountered in the same episodic context. The complementary characteristics of these subfields explain how we can parse our experiences into cohesive episodes while retaining the specific details that support vivid recollection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.