Evidence map›Paper›PMID 29348316›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Evaluation of Next-Generation Anti-CD20 Antibodies Labeled with

Jason T Yoon, Mark S Longtine, Bernadette V Marquez-Nostra, Richard L Wahl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Biodistribution ofACS omega · 2025
    Article
  4. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  5. Review
  6. Evaluation of Candidate Theranostics forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  7. Cure of Disseminated Human Lymphoma with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  8. Cure of Disseminated Human Lymphoma with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  9. Tumor Targeting ofMolecular pharmaceutics · 2023
    Article
  10. Review
  11. Noninvasive Evaluation of CD20 Expression UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  12. Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  13. Review
  14. Frontiers in immunology · 2020
    Review
  15. Antibody-Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases.Chembiochem : a European journal of chemical biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jason T YoonMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Mark S LongtineMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Bernadette V Marquez-NostraMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Richard L WahlMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri wahlr@wustl.edu.
Mallinckrodt (United States) · US

Funding

IMAGING FOR ASSESSMENT AND PREDICTION OF RESPONSE TO THERAPY FOR TRIPLE NEGATIVE BREAST CANCERK99CA201601 · NCI · WASHINGTON UNIVERSITY · PI MARQUEZ-NOSTRA, BERNADETTE · 2016 to 2017
$191k
NCI NIH HHS K99 CA201601
6 · The paper itself

Abstract

Radioimmunotherapies with monoclonal antibodies to the B-lymphocyte antigen 20 (CD20) are effective treatments for B-cell lymphomas, but U.S. Food and Drug Administration-approved radioimmunotherapies exclusively use radiolabeled murine antibodies, potentially limiting redosing. The Food and Drug Administration recently approved 2 unlabeled anti-CD20 monoclonal antibodies, obinutuzumab and ofatumumab, termed next generation as they are humanized (obinutuzumab) or fully human (ofatumumab), thus potentially allowing a greater potential for redosing than with previous-generation anti-CD20 antibodies, including rituximab (chimeric) and tositumomab (murine), which contain more murine peptide sequences. We prepared

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigens, CD20Cell Line, TumorCell Transformation, NeoplasticFemaleHumansIsotope LabelingLymphomaMicePositron Emission Tomography Computed TomographyRadiochemistryRadioimmunotherapyRadioisotopesTissue DistributionAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigens, CD20obinutuzumabofatumumabRadioisotopesZirconiumZirconium-89CD20lymphomapositron emission tomographytargeted antibodies

Identifiers

PMID29348316
PMCPMC6071500
OpenAlexW2784960772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.