Evidence map›Paper›PMID 29348267›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

Toll-Like Receptor 9-Dependent AMPK

Cameron G McCarthy, Camilla F Wenceslau, Safia Ogbi, Theodora Szasz, R Clinton Webb

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. TAK1 in Vascular Signaling: "Friend or Foe"?Journal of inflammation research · 2024
    Review
  2. Article
  3. Article
  4. The WNT/CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. SLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Guidelines for the measurement of vascular function and structure in isolated arteries and veins.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  10. Vascular Stress Signaling in Hypertension.Circulation research · 2021
    Review
  11. Review
  12. L-arginase induces vascular dysfunction in old spontaneously hypertensive rats.Journal of African Association of Physiological Sciences · 2019
    Article
  13. Article
  14. Paying the Toll for Inflammation.Hypertension (Dallas, Tex. : 1979) · 2019
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cameron G McCarthyDepartment of Physiology, Augusta University, Augusta, Georgia cmccarthy@augusta.edu.
Camilla F WenceslauDepartment of Physiology, Augusta University, Augusta, Georgia.
Safia OgbiDepartment of Physiology, Augusta University, Augusta, Georgia.
Theodora SzaszDepartment of Physiology, Augusta University, Augusta, Georgia.
R Clinton WebbDepartment of Physiology, Augusta University, Augusta, Georgia.
Augusta University · US

Funding

Toll-like receptor 9 activation by mitochondrial DNA causes vascular injury in hypertensionP01HL134604 · NHLBI · AUGUSTA UNIVERSITY · PI O'CONNOR, PAUL MICHAEL · 2017 to 2021
$9.4M
Intrarenal Arteries Sense Trauma-derived Mitochondrial N-formyl Peptides Leading to Kidney Injury in SIRSK99GM118885 · NIGMS · AUGUSTA UNIVERSITY · PI WENCESLAU, CAMILLA FERREIRA · 2016 to 2017
$162k
NHLBI NIH HHS P01 HL134604NIGMS NIH HHS K99 GM118885
6 · The paper itself

Abstract

Traditionally, Toll-like receptor 9 (TLR9) signals through an MyD88-dependent cascade that results in proinflammatory gene transcription. Recently, it was reported that TLR9 also participates in a stress tolerance signaling cascade in nonimmune cells. In this noncanonical pathway, TLR9 binds to and inhibits sarcoplasmic/endoplasmic reticulum Ca

Indexed as

Protein MultimerizationActinsAMP-Activated Protein KinasesAnimalsEnzyme ActivationGene Expression Regulation, EnzymologicMaleMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMuscle, Smooth, VascularPhosphorylationProtein Structure, QuaternaryRatsRats, Sprague-DawleyrhoA GTP-Binding Proteinrho-Associated KinasesActinsAMP-Activated Protein KinasesMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesrhoA GTP-Binding Proteinrho-Associated KinasesToll-Like Receptor 9

Identifiers

PMID29348267
PMCPMC5830639
OpenAlexW2791730577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.