ArticleArteriosclerosis, thrombosis, and vascular biology2018
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
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28 citing papers in PubMed, 48 citations in OpenAlex.
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- Genetic interaction between oxidative stress and body mass index in a Spanish population.Redox biology · 2025Article
- High-density lipoprotein revisited: biological functions and clinical relevance.European heart journal · 2023Review
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- Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.Diabetes · 2023Article
- Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus.Hereditas · 2022Article
- The effect of ABCA1 gene DNA methylation on blood pressure levels in a Chinese hyperlipidemic population.Journal of human hypertension · 2021Article
- ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease.BMC cardiovascular disorders · 2021Article
- Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Uncurtaining the pivotal role of ABC transporters in diabetes mellitus.Environmental science and pollution research international · 2021Review
- Role of Tim4 in the regulation of ABCA1Nature communications · 2021Article
- Molecular mechanisms detected in yak lung tissue via transcriptome-wide analysis provide insights into adaptation to high altitudes.Scientific reports · 2021Article
- The prorenin receptor and its soluble form contribute to lipid homeostasis.American journal of physiology. Endocrinology and metabolism · 2021Article
- Is it possible ABC transporters genetic variants influence the outcomes of a weight-loss diet in obese women?Genetics and molecular biology · 2020Article
- Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile.Biomolecules · 2020Article
- Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes.International journal of obesity (2005) · 2020Article
- The Landscape of DNA Methylation Associated With the Transcriptomic Network of Intramuscular Adipocytes Generates Insight Into Intramuscular Fat Deposition in Chicken.Frontiers in cell and developmental biology · 2020Article
- Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020Review
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Authors and funding
10 authors at 1 institution in 1 country.
Helen CuffeFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Mingxia LiuFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Chia-Chi C KeyFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Elena BoudyguinaFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Janet K SawyerFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Allison WeckerleFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Alexander BashoreFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Susan K FriedFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
Soonkyu ChungFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.).
John S ParksFrom the Section on Molecular Medicine, Department of Internal Medicine (H.C., M.L., C.-C.C.K., E.B., J.K.S., A.W., A.B., J.S.P.) and Department of Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York (S.K.F.); and Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE (S.C.). jparks@wakehealth.edu.
Icahn School of Medicine at Mount Sinai · US
Funding
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MThe Role of Hepatocyte ABCA1 in Lipid Mobilization and TransportR01HL119962 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARKS, JOHN S · 2013 to 2022
$3.9MIntegrative Lipid Metabolism, Inflammation, and Chronic DiseasesT32HL091797 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARKS, JOHN S · 2008 to 2017
$1.8MNCATS NIH HHS UL1 TR001420NHLBI NIH HHS R01 HL119962NHLBI NIH HHS T32 HL091797NIDDK NIH HHS P30 DK020541
Abstract
objectiveAdipose tissue cholesterol increases with adipocyte triglyceride content and size during development of obesity. However, how adipocyte cholesterol affects adipocyte function is poorly understood. The aim of this study was to evaluate the role of the cellular cholesterol exporter, Abca1 (ATP-binding cassette transporter A1), on adipose tissue function during diet-induced obesity. APPROACH AND
resultsAdiponectin
conclusionsAdipocyte Abca1 is a key regulator of adipocyte lipogenesis and lipid accretion, likely because of increased adipose tissue membrane cholesterol, resulting in decreased activation of lipogenic transcription factors PPARγ and SREBP1.
Indexed as
Cholesterol, DietaryDiet, High-FatGene DeletionLipolysis3T3-L1 CellsAdipocytesAdipogenesisAdipose TissueAnimalsATP Binding Cassette Transporter 1Disease Models, AnimalGenetic Predisposition to DiseaseMaleMiceMice, Inbred C57BLMice, KnockoutAbca1 protein, mouseATP Binding Cassette Transporter 1Cholesterol, DietaryPPAR gammaSrebf1 protein, mouseSterol Regulatory Element Binding Protein 1Triglyceridesadipose tissueanimalscholesterolmiceobesity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.