Evidence map›Paper›PMID 29348025›Full record

ArticleJournal of the American College of Cardiology2018

PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.

Max L Senders, Xuchu Que, Young Seok Cho, Calvin Yeang, Hannah Groenen, Francois Fay, Claudia Calcagno, Anu E Meerwaldt, Simone Green, Phuong Miu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Inflammation and Immune Mechanisms in Atherosclerosis.Reviews in cardiovascular medicine · 2026
    Review
  4. CD8Nature reviews. Cardiology · 2026
    Review
  5. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Human circulating CD24Nature cardiovascular research · 2023
    Article
  11. Lipoprotein (a), Inflammation, and Atherosclerosis.Journal of clinical medicine · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Max L SendersTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, the Netherlands.
Xuchu QueDivision of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.
Young Seok ChoSeoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, South Korea; Division of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California.
Calvin YeangDivision of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California.
Hannah GroenenTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Francois FayTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Chemistry and Pharmaceutical Science, York College of The City University of New York, New York, New York.
Claudia CalcagnoTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Anu E MeerwaldtTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Simone GreenDivision of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California.
Phuong MiuDivision of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California.
Mark E LobattoDepartment of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Radiology, Weill Cornell Medical College, New York, New York.
Zahi A FayadTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Joseph L WitztumDivision of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California.
Willem J M MulderTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, the Netherlands.
Carlos Pérez-MedinaTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: carlos.perez-medina@mountsinai.org.
Sotirios TsimikasDivision of Cardiovascular Diseases, Sulpizio Cardiovascular Center, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: stsimikas@ucsd.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
ROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI TAYLOR, ANGELA M · 1995 to 2016
$28.4M
Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4M
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3M
Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular HomeostasisR01HL106579 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2011 to 2022
$8.3M
Targeted CEU Imaging of Atherosclerosis and AngiogenesisR01HL078610 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2022
$6.8M
AIBP therapyR35HL135737 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY · 2017 to 2023
$6.5M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
PET/MRI to study nanotherapy in atherosclerosisR01HL125703 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MULDER, WILLEM · 2015 to 2018
$2.4M
Oxidation-specific nanoparticles for imaging atherosclerosisR01HL119828 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TSIMIKAS, SOTIRIOS · 2013 to 2017
$2.0M
NCI NIH HHS P30 CA008748NHLBI NIH HHS P01 HL055798NHLBI NIH HHS P01 HL088093NHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL078610NHLBI NIH HHS R01 HL106579NHLBI NIH HHS R01 HL119828NHLBI NIH HHS R01 HL125703NHLBI NIH HHS R01 HL128550NHLBI NIH HHS R01 HL136098NHLBI NIH HHS R35 HL135737NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

backgroundOxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events.

objectivesThe purpose of this study was to develop novel positron emission tomography (PET) probes to noninvasively image OSE-rich lesions.

methodsAn antigen-binding fragment (Fab) antibody library was constructed from human fetal cord blood. After multiple rounds of screening against malondialdehyde-acetaldehyde (MAA) epitopes, the Fab LA25 containing minimal nontemplated insertions in the CDR3 region was identified and characterized. In mice, pharmacokinetics, biodistribution, and plaque specificity studies were performed with Zirconium-89 (

resultsLA25 bound specifically to MAA epitopes in advanced and ruptured human atherosclerotic plaques with accompanying thrombi and in debris from distal protection devices. PET/MR imaging 24 h after injection of

conclusions

Indexed as

AcetaldehydeMalondialdehydeAnimalsAtherosclerosisEpitopesHumansMagnetic Resonance ImagingMiceMice, KnockoutPositron-Emission TomographyRabbitsThrombosisTissue DistributionAcetaldehydeEpitopesMalondialdehydeatherosclerosisnatural antibodiesoxidation-specific epitopesPET/MR imaging

Identifiers

PMID29348025
PMCPMC5995462

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.