ArticleCritical care (London, England)2018
Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study.
Article in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition.Critical care (London, England) · 2023Guideline
- The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis.BMC pulmonary medicine · 2019Pooled it
- Electronic Medical Record-Based Pager Notification Reduces Excess Oxygen Exposure in Mechanically Ventilated Subjects.Respiratory care · 2021Trial
- Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.EBioMedicine · 2018Trial
- Determinants of Brain Tissue Normoxia in Patients with Large Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Management of Mechanical Ventilation in Emergency Medicine: A Scoping Review.Journal of the American College of Emergency Physicians open · 2026Review
- Is hyperoxia during veno-arterial extracorporeal life support due to cardiopulmonary failure associated with mortality in pediatric patients?The journal of extra-corporeal technology · 2025Article
- Is hyperoxia in early pediatric veno-veno extracorporeal life support associated with mortality?The journal of extra-corporeal technology · 2025Article
- Peripheral oxygen saturation levels as a guide to avoid hyperoxia: an observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Association Between Early Hyperoxemia Exposure and Intensive Care Unit Mortality in Intracerebral Hemorrhage: An Observational Cohort Analysis.Neurocritical care · 2024Observational
- Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation.The journal of extra-corporeal technology · 2024Article
- Respiratory Therapist-Driven Mechanical Ventilation Protocol Is Associated With Increased Lung Protective Ventilation.Respiratory care · 2024Article
- Hyperoxia and brain: the link between necessity and injury from a molecular perspective.Neurotoxicity research · 2024Review
- Closed-loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study.Frontiers in medicine · 2024Article
- Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries.Antioxidants (Basel, Switzerland) · 2023Review
- Changes of blood gas analysis in moderate-to-severe acute respiratory distress syndrome patients during long-term prone position ventilation: a retrospective cohort study.Annals of translational medicine · 2023Article
- Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation.Critical care (London, England) · 2022Article
- Rationale and design of a randomized controlled clinical trial; Titration of Oxygen Levels (TOOL) during mechanical ventilation.Contemporary clinical trials · 2022Article
- Early Titration of Oxygen During Mechanical Ventilation Reduces Hyperoxemia in a Pilot, Feasibility, Randomized Control Trial for Automated Titration of Oxygen Levels.Critical care explorations · 2022Article
- Supplemental oxygen administration during mechanical ventilation reduces diaphragm blood flow and oxygen delivery.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundProviding supplemental oxygen is fundamental in the management of mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes associated with hyperoxia. However, these previous data in the critically ill have not focused on outcomes associated with brief hyperoxia exposure immediately after endotracheal intubation. Therefore, the objectives of this study were to evaluate the impact of isolated early hyperoxia exposure in the emergency department (ED) on clinical outcomes among mechanically ventilated patients with subsequent normoxia in the intensive care unit (ICU).
methodsThis was an observational cohort study conducted in the ED and ICUs of an academic center in the USA. Mechanically ventilated normoxic (partial pressure of arterial oxygen (P
resultsA total of 688 patients were included. ED normoxia occurred in 350 (50.9%) patients, and 300 (43.6%) had exposure to ED hyperoxia. The ED hyperoxia group had a median (IQR) ED P
conclusionsED exposure to hyperoxia is common and associated with increased mortality in mechanically ventilated patients achieving normoxia after admission. This suggests that hyperoxia in the immediate post-intubation period could be particularly injurious, and targeting normoxia from initiation of mechanical ventilation may improve outcome.
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