Evidence map›Paper›PMID 29347968›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2018

Ralf S Eschbach, Philipp M Kazmierczak, Maurice M Heimer, Andrei Todica, Heidrun Hirner-Eppeneder, Moritz J Schneider, Georg Keinrath, Olga Solyanik, Jessica Olivier, Wolfgang G Kunz and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Longitudinal evaluation of five nasopharyngeal carcinoma animal models on the microPET/MR platform.European journal of nuclear medicine and molecular imaging · 2022
    Article
  4. Article
  5. Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors.International journal of molecular sciences · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Ralf S EschbachDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany. ralf.eschbach@med.lmu.de.
Philipp M KazmierczakDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Maurice M HeimerDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Andrei TodicaDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Heidrun Hirner-EppenederDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Moritz J SchneiderDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Georg KeinrathDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Olga SolyanikDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Jessica OlivierDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Wolfgang G KunzDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Maximilian F ReiserDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Jens RickeDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Clemens C CyranDepartment of Radiology, Laboratory for Experimental Radiology, University Hospital, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, München, Germany.
Ludwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by

methodsHuman BRAF-V600-mutant melanoma (A375) xenograft-bearing balb/c nude mice (n = 21) were imaged by

resultsTumor glucose uptake was significantly suppressed under therapy (∆TTL

conclusionA novel BRAF and CDK 4/6 inhibitor combination therapy exhibited significant anti-angiogenic and anti-proliferative effects in experimental human melanomas, monitored by

Indexed as

AminopyridinesAnimalsAntineoplastic AgentsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Diffusion Magnetic Resonance ImagingFemaleFluorodeoxyglucose F18ImidazolesMaleMelanomaMiceMice, Inbred BALB CMice, NudeOximesPositron Emission Tomography Computed TomographyAminopyridinesAntineoplastic AgentsBraf protein, mouseCdk4 protein, mouseCdk6 protein, mouseCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6dabrafenibFluorodeoxyglucose F18ImidazolesOximesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafPurinesRadiopharmaceuticalsribociclib18F–FDG-PETBRAF inhibitorCDK inhibitorDiffusion-weighted MRIMelanomaTherapy monitoring

Identifiers

PMID29347968
PMCPMC5774089
OpenAlexW2791111401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.