ArticleParasites & vectors2018
A reverse vaccinology approach to the identification and characterization of Ctenocephalides felis candidate protective antigens for the control of cat flea infestations.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Bottom-Up Proteomics Workflow for Studying Multi-organism Systems.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Salivary glands of the cat flea,Current research in insect science · 2024Review
- Using Proteomic Approaches to Unravel the Response ofFrontiers in cellular and infection microbiology · 2022Article
- Article
- Molecular tools-advances, opportunities and prospects for the control of parasites of veterinary importance.International journal of tropical insect science · 2021Review
- Recent Advancements in the Control of Cat Fleas.Insects · 2020Review
- Coronavirus in cat flea: findings and questions regarding COVID-19.Parasites & vectors · 2020Article
- Computational tools for modern vaccine development.Human vaccines & immunotherapeutics · 2020Review
- Vaccination with Ectoparasite Proteins Involved in Midgut Function and Blood Digestion Reduces Salmon Louse Infestations.Vaccines · 2020Article
- Why New Vaccines for the Control of Ectoparasite Vectors Have Not Been Registered and Commercialized?Vaccines · 2019Article
- Identification of relevant regions on structural and nonstructural proteins ofNew microbes and new infections · 2019Article
- A Vaccinomics Approach for the Identification of Tick Protective Antigens for the Control ofFrontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDespite the abundance of the domestic cat flea, Ctenocephalides felis (Bouché, 1835) and disease risks associated with them, flea control is difficult and requires the development of new control interventions such as vaccines. In this study, a reverse vaccinology approach was designed to achieve a rational selection of cat flea candidate protective antigens.
methodsBased on transcriptomics and proteomics data from unfed adult fleas it was possible to select more specific candidate protective antigens based on highly represented and functionally relevant proteins present in the predicted exoproteome. The protective capacity of the recombinant antigens was evaluated for the control of C. felis infestations in vaccinated cats.
resultsVaccination with recombinant antigens induced an antibody response in immunized cats. Furthermore, a correlation was obtained between the effect of vaccination (antibody levels) and vaccine efficacy on flea phenotype (egg hatchability). The results suggested that the main effect of vaccination with these antigens was on reducing cat flea egg hatchability and fertility, with an overall vaccine efficacy of 32-46%. Although vaccination with these antigens did not have an effect on flea infestations, vaccines affecting reproductive capacity could reduce cat flea populations, particularly under conditions of direct insect transmission between cats.
conclusionsThese results support the development of vaccines with protective antigens affecting flea reproduction and development after feeding on immunized animals for the control of cat flea infestations.
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