Evidence map›Paper›PMID 29347935›Full record

Observational studyBMC women's health2018

Real-world experience of women using extended-cycle vs monthly-cycle combined oral contraception in the United States: the National Health and Wellness Survey.

Rossella E Nappi, Iñaki Lete, Lulu K Lee, Natalia M Flores, Marie-Christine Micheletti, Boxiong Tang

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in BMC women's health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Contraception and Amenorrhea: An Exploratory Cross-Sectional Study on Acceptability in Filipino/Filipino-American Women.Journal of transcultural nursing : official journal of the Transcultural Nursing Society · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Rossella E NappiResearch Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS Policlinico San Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Piazzale Golgi 2, 27100, Pavia, Italy. renappi@tin.it.
Iñaki LeteAraba University Hospital, Jose Atxotegi Street, Vitoria, Spain.
Lulu K LeeKantar Health, 393 Vintage Park Drive, Suite 100, Foster City, CA, USA.
Natalia M FloresKantar Health, 393 Vintage Park Drive, Suite 100, Foster City, CA, USA.
Marie-Christine MichelettiTeva Europe Women's Health, Piet Heinkade 107, Amsterdam, The Netherlands.
Boxiong TangTeva Pharmaceuticals, 41 Moores Road, Frazer, PA, USA.
Kantar Health (United States) · USHospital Universitario Araba · ESTeva Pharmaceuticals (United States) · USUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe real-world experience of women receiving extended-cycle combined oral contraception (COC) versus monthly-cycle COC has not been reported.

methodsData were from the United States 2013 National Health and Wellness Survey. Eligible women (18-50 years old, premenopausal, without hysterectomy) currently using extended-cycle COC (3 months between periods) were compared with women using monthly-cycle COC. Treatment satisfaction (1 "extremely dissatisfied" to 7 "extremely satisfied"), adherence (8-item Morisky Medication Adherence Scale

resultsParticipants included 260 (6.7%) women using extended-cycle and 3616 (93.3%) using monthly-cycle COC. Women using extended-cycle COC reported significantly higher treatment satisfaction (P = 0.001) and adherence (P = 0.04) and reduced heavy menstrual bleeding (P = 0.029). A non-significant tendency toward reduced menstrual pain (39.5% versus 47.3%) and menstrual cycle-related symptoms (40.0% versus 48.7%) was found in women using extended-cycle versus monthly-cycle COC. Significantly more women using extended-cycle COC reported health-related diagnoses, indicating preferential prescription for extended-cycle COC among women reporting more health problems. Consistent with this poorer health, more women using extended-cycle COC reported fatigue, headache, and activity impairment (P values < 0.05). There were no other significant differences between groups.

conclusionsThis real-world observational study supports extended-cycle COC as a valuable treatment option with high satisfaction, high adherence, and reduced heavy menstrual bleeding.

Indexed as

Patient Outcome AssessmentAdolescentAdultContraceptives, Oral, CombinedDrug Administration ScheduleFemaleHealth SurveysHumansMedication AdherenceMenstrual CycleMenstruation DisturbancesMiddle AgedPatient SatisfactionQuality of LifeUnited StatesYoung AdultContraceptives, Oral, CombinedAdherenceExtended-regimenHeavy menstrual bleedingHormonal contraceptionMenstrual cycleReal-worldSatisfactionWomen’s health

Identifiers

PMID29347935
PMCPMC5774154
OpenAlexW2788387219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.