ArticleBMC biology2018
Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.
Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The importance of non-coding RNAs in environmental stress-related developmental brain disorders: A systematic review of evidence associated with exposure to alcohol, anesthetic drugs, nicotine, and viral infections.Neuroscience and biobehavioral reviews · 2021Pooled it
- Hydrogen sulfide as a potent predator-derived kairomone mediating fear-related responses in mice.Communications biology · 2025Article
- Behavioral and neurobiological implications of kairomones for rodents: an updated review.Frontiers in neuroscience · 2025Review
- Ocular Symptoms Associated with COVID-19 Are Correlated with the Expression Profile of Mouse SARS-CoV-2 Binding Sites.Viruses · 2023Article
- From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion.Animals : an open access journal from MDPI · 2022Article
- Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms.Communications biology · 2021Article
- Bcl11b is required for proper odorant receptor expression in the mouse septal organ.Cell and tissue research · 2021Article
- An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The acoustic startle reflex as a tool for assessment of odor environment effects on affective states in laboratory mice.Experimental animals · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- The Grueneberg ganglion: signal transduction and coding in an olfactory and thermosensory organ involved in the detection of alarm pheromones and predator-secreted kairomones.Cell and tissue research · 2021Review
- Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish.Cell and tissue research · 2021Review
- The Grueneberg ganglion controls odor-driven food choices in mice under threat.Communications biology · 2020Article
- Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Identifying Isl1 Genetic Lineage in the Developing Olfactory System and in GnRH-1 Neurons.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only beginning to be characterized.
resultsScreening chemical libraries for compounds structurally resembling the already-identified GG ligands, we found a new category of chemicals previously identified as bitter tastants that initiated fear-related behaviours in mice depending on their volatility and evoked neuronal responses in mouse GG neurons. Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein α-gustducin (Gnat3). We were further able to confirm their expression at the protein level. Challenging these three G protein-coupled receptors in a heterologous system with the known GG ligands, we identified TAS2R143 as a chemical danger receptor transducing both alarm pheromone and predator-derived kairomone signals.
conclusionsThese results demonstrate that similar molecular elements might be used by the GG and by the taste system to detect chemical danger signals present in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.