ArticlePhysical review. E2017
Elucidating distinct ion channel populations on the surface of hippocampal neurons via single-particle tracking recurrence analysis.
Article in Physical review. E, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 41 citations in OpenAlex.
- Concurrent diffusion of nicotinic acetylcholine receptors and fluorescent cholesterol disclosed by two-colour sub-millisecond MINFLUX-based single-molecule tracking.Nature communications · 2025Article
- Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating.Physics in medicine and biology · 2023Article
- Heterogeneous nanoscopic lipid diffusion in the live cell membrane and its dependency on cholesterol.Biophysical journal · 2022Article
- Precise Detection and Visualization of Nanoscale Temporal Confinement in Single-Molecule Tracking Analysis.Membranes · 2022Article
- Objective comparison of methods to decode anomalous diffusion.Nature communications · 2021Article
- Detecting Transient Trapping from a Single Trajectory: A Structural Approach.Entropy (Basel, Switzerland) · 2021Article
- The NaFrontiers in pharmacology · 2021Article
- The Specific Effects of OD-1, a Peptide Activator, on Voltage-Gated Sodium Current and Seizure Susceptibility.International journal of molecular sciences · 2020Article
- The MAP1B Binding Domain of NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking.Scientific reports · 2019Article
- Identifying diffusive motions in single-particle trajectories on the plasma membrane via fractional time-series models.Physical review. E · 2019Article
- Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability.Scientific reports · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Protein and lipid nanodomains are prevalent on the surface of mammalian cells. In particular, it has been recently recognized that ion channels assemble into surface nanoclusters in the soma of cultured neurons. However, the interactions of these molecules with surface nanodomains display a considerable degree of heterogeneity. Here, we investigate this heterogeneity and develop statistical tools based on the recurrence of individual trajectories to identify subpopulations within ion channels in the neuronal surface. We specifically study the dynamics of the K^{+} channel Kv1.4 and the Na^{+} channel Nav1.6 on the surface of cultured hippocampal neurons at the single-molecule level. We find that both these molecules are expressed in two different forms with distinct kinetics with regards to surface interactions, emphasizing the complex proteomic landscape of the neuronal surface. Further, the tools presented in this work provide new methods for the analysis of membrane nanodomains, transient confinement, and identification of populations within single-particle trajectories.
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