ArticleCell reports2018
Cell-Type Specificity of Callosally Evoked Excitation and Feedforward Inhibition in the Prefrontal Cortex.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Article
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.Molecular psychiatry · 2025Article
- Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer's model mice.Communications biology · 2025Article
- Afferent-specific modulation of excitatory synaptic transmission by acetylcholine and serotonin in the prelimbic cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.bioRxiv : the preprint server for biology · 2025Article
- Effect of juvenile social isolation on excitability of prefrontal pyramidal cells with different subcortical axonal projections.Frontiers in cellular neuroscience · 2025Article
- A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation.Nature communications · 2024Article
- Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity.eNeuro · 2024Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- CCK+ Interneurons Contribute to Thalamus-Evoked Feed-Forward Inhibition in the Prelimbic Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Symmetry in frontal but not motor and somatosensory cortical projections.bioRxiv : the preprint server for biology · 2024Article
- Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
3 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Excitation and inhibition are highly specific in the cortex, with distinct synaptic connections made onto subtypes of projection neurons. The functional consequences of this selective connectivity depend on both synaptic strength and the intrinsic properties of targeted neurons but remain poorly understood. Here, we examine responses to callosal inputs at cortico-cortical (CC) and cortico-thalamic (CT) neurons in layer 5 of mouse prelimbic prefrontal cortex (PFC). We find callosally evoked excitation and feedforward inhibition are much stronger at CT neurons compared to neighboring CC neurons. Elevated inhibition at CT neurons reflects biased synaptic inputs from parvalbumin and somatostatin positive interneurons. The intrinsic properties of postsynaptic targets equalize excitatory and inhibitory response amplitudes but selectively accelerate decays at CT neurons. Feedforward inhibition further reduces response amplitude and balances action potential firing across these projection neurons. Our findings highlight the synaptic and cellular mechanisms regulating callosal recruitment of layer 5 microcircuits in PFC.
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