ArticleCell reports2018
Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Systematic review: The gut microbiota as a link between colorectal cancer and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Obesity-driven microbial GABA depletion promotes metabolic rewiring and colorectal cancer progression.Nature communications · 2026Article
- Chronic High-Fat Diet Does Not Alter Overall Cancer Incidence in Trp53R270H/+ Mice.Cancer research communications · 2026Article
- Diet-induced chromatin states influence intestinal stem cell memory.bioRxiv : the preprint server for biology · 2026Article
- Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.Neoplasia (New York, N.Y.) · 2025Article
- Obesity as a risk factor for early-onset colorectal cancer: Evidence from a nationally representative database.World journal of clinical oncology · 2025Article
- Single-cell transcriptome analysis reveals immunosuppressive landscape in overweight and obese colorectal cancer.Journal of translational medicine · 2024Article
- Epigenetic modifications in obesity-associated diseases.MedComm · 2024Review
- DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine.Exploration of targeted anti-tumor therapy · 2024Review
- Review
- Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet.Scientific reports · 2023Article
- Metabolism, metabolites, and macrophages in cancer.Journal of hematology & oncology · 2023Review
- Obesity associated cancers, genetics, epigenetics and elephants.Journal of translational genetics and genomics · 2023Article
- Risk factors for early-onset colorectal cancer: systematic review and meta-analysis.Frontiers in oncology · 2023Review
- Epigenetic effects of high-fat diet on intestinal tumorigenesis in C57BL/6J-Journal of translational genetics and genomics · 2023Article
- Alterations of DNA methylation and expression of genes related to thyroid hormone metabolism in colon epithelium of obese patients.BMC medical genomics · 2022Article
- Microenvironmental influences on T cell immunity in cancer and inflammation.Cellular & molecular immunology · 2022Review
- Review
- Metabolic Profiling of Neocortical Tissue Discriminates Alzheimer's Disease from Mild Cognitive Impairment, High Pathology Controls, and Normal Controls.Journal of proteome research · 2021Article
- How Comorbidities Shape Cancer Biology and Survival.Trends in cancer · 2021Review
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9 authors at 4 institutions in 1 country.
Funding
Abstract
Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups. The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain poorly understood. Using a diet-induced obesity mouse model, we identified obesity-associated molecular changes in the colonic epithelium of young and aged mice, and we further investigated whether the changes were reversed after weight loss. Transcriptome analysis indicated that obesity-related colonic cellular metabolic switch favoring long-chain fatty acid oxidation happened in young mice, while obesity-associated downregulation of negative feedback regulators of pro-proliferative signaling pathways occurred in older mice. Strikingly, colonic DNA methylome was pre-programmed by obesity at young age, priming for a tumor-prone gene signature after aging. Furthermore, obesity-related changes were substantially preserved after short-term weight loss, but they were largely reversed after long-term weight loss. We provided mechanistic insights into increased CRC risk in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.