ArticleCell reports2018
INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The Prion-Like Properties of the INO80 Chromatin Remodeler Regulate Metabolic Gene Expression.bioRxiv : the preprint server for biology · 2026Article
- Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions.MedComm · 2026Review
- The Ies6 subunit is essential for INO80-mediated nucleosome organization.Scientific reports · 2026Article
- COMPASS subunit Bre2 regulates chromatin remodeler Arp9 to control Aspergillus flavus aflatoxin synthesis and virulence.Nature communications · 2026Article
- Article
- A dual reporter system for intracellular and extracellular amino acid sensing in budding yeast.Molecular biology of the cell · 2025Article
- A four eigen-phase model of multi-omics unveils new insights into yeast metabolic cycle.NAR genomics and bioinformatics · 2025Article
- Obtaining new brewing yeasts using regional Chilean wine yeasts through an adaptive evolution program.Frontiers in microbiology · 2025Article
- Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle.PloS one · 2025Article
- Uncharacterized yeast geneeLife · 2024Article
- INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation.International journal of molecular sciences · 2022Article
- Distinct functions of three chromatin remodelers in activator binding and preinitiation complex assembly.PLoS genetics · 2022Article
- Article
- Cancer cell metabolism connects epigenetic modifications to transcriptional regulation.The FEBS journal · 2022Review
- Uncovering Divergence in Gene Expression Regulation in the Adaptation of Yeast to Nitrogen Scarcity.mSystems · 2021Article
- Epigenomic links from metabolism-methionine and chromatin architecture.Current opinion in chemical biology · 2021Review
- Article
- TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae.BMC biology · 2021Article
- Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis.Scientific reports · 2021Article
- Chromatin-remodeling links metabolic signaling to gene expression.Molecular metabolism · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression. Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression. Collectively, these results reveal that the INO80 complex mediates metabolic signaling to chromatin to restrict proliferation to metabolically optimal states.
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Registered trials
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