ArticleMolecular biology and evolution2018
The Evolutionary History of Nebraska Deer Mice: Local Adaptation in the Face of Strong Gene Flow.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
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- Demographic history and genomic signatures of selection in a widespread vertebrate ectotherm.Molecular ecology · 2024Article
- Local adaptation with gene flow in a highly dispersive shark.Evolutionary applications · 2024Article
- Genomic signals of local adaptation across climatically heterogenous habitats in an invasive tropical fruit fly (Bactrocera tryoni).Heredity · 2024Article
- Candidate genes under selection in song sparrows co-vary with climate and body mass in support of Bergmann's Rule.Nature communications · 2023Article
- Genomic architecture of migration timing in a long-distance migratory songbird.Scientific reports · 2023Article
- Rapid and predictable genome evolution across three hybrid ant populations.PLoS biology · 2022Article
- Local adaptation: Causal agents of selection and adaptive trait divergence.Annual review of ecology, evolution, and systematics · 2022Article
- Evolutionary Genomics of a Subdivided Species.Molecular biology and evolution · 2022Article
- An enhancer ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Whole-genome analysis of multiple wood ant population pairs supports similar speciation histories, but different degrees of gene flow, across their European ranges.Molecular ecology · 2022Article
- Habitat-linked genetic variation supports microgeographic adaptive divergence in an island-endemic bird species.Molecular ecology · 2022Article
- The response of a metapopulation to a changing environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Genetic isolation by distance underlies colour pattern divergence in red-eyed treefrogs (Agalychnis callidryas).Molecular ecology · 2022Article
- Local adaptation to climate anomalies relates to species phylogeny.Communications biology · 2022Article
- Genetic guidelines for translocations: Maintaining intraspecific diversity in the lion (Evolutionary applications · 2022Article
- Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions.Ecology and evolution · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
The interplay of gene flow, genetic drift, and local selective pressure is a dynamic process that has been well studied from a theoretical perspective over the last century. Wright and Haldane laid the foundation for expectations under an island-continent model, demonstrating that an island-specific beneficial allele may be maintained locally if the selection coefficient is larger than the rate of migration of the ancestral allele from the continent. Subsequent extensions of this model have provided considerably more insight. Yet, connecting theoretical results with empirical data has proven challenging, owing to a lack of information on the relationship between genotype, phenotype, and fitness. Here, we examine the demographic and selective history of deer mice in and around the Nebraska Sand Hills, a system in which variation at the Agouti locus affects cryptic coloration that in turn affects the survival of mice in their local habitat. We first genotyped 250 individuals from 11 sites along a transect spanning the Sand Hills at 660,000 single nucleotide polymorphisms across the genome. Using these genomic data, we found that deer mice first colonized the Sand Hills following the last glacial period. Subsequent high rates of gene flow have served to homogenize the majority of the genome between populations on and off the Sand Hills, with the exception of the Agouti pigmentation locus. Furthermore, mutations at this locus are strongly associated with the pigment traits that are strongly correlated with local soil coloration and thus responsible for cryptic coloration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.