ArticleMolecular biology and evolution2018
Accumulation of Mutational Load at the Edges of a Species Range.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 124 citations in OpenAlex.
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- Census and genetic analysis of the United States marmoset population.bioRxiv : the preprint server for biology · 2026Article
- Limited directional selection but coevolutionary signals among imprinted genes inbioRxiv : the preprint server for biology · 2026Article
- Joint test of historical vs. contemporary biogeography supports abundant center hypothesis shaping spatial patterns of self-fertilization.Evolution letters · 2026Article
- Shared historical refugia and genetic diversity hotspots of co-distributed species on the Qinghai Tibet plateau.iScience · 2026Article
- An alpine plant shows no decrease in genetic diversity associated with rapid post-glacial range expansion.American journal of botany · 2025Article
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sampling effect in predicting the evolutionary response of populations to climate change.Molecular ecology resources · 2025Article
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- The Demographic History of Populations and Genomic Imprinting have Shaped the Transposon Patterns in Arabidopsis lyrata.Molecular biology and evolution · 2025Article
- SNP-RFLP Markers for the Study ofEcology and evolution · 2025Article
- Genomic implications of the repeated shift to self-fertilization across a species' geographic distribution.The Journal of heredity · 2025Article
- Too big to purge: persistence of deleterious Mutations in Island populations of the European Barn Owl (Tyto alba).Heredity · 2024Article
- Lineage Differentiation and Genomic Vulnerability in a Relict Tree From Subtropical Forests.Evolutionary applications · 2024Article
- The genetic architecture of repeated local adaptation to climate in distantly related plants.Nature ecology & evolution · 2024Article
- Marine fishes experiencing high-velocity range shifts may not be climate change winners.Nature ecology & evolution · 2024Article
- Limited effects of population age on the genetic structure of spatially isolated forest herb populations in temperate Europe.Ecology and evolution · 2024Article
- Genome size variation and evolution during invasive range expansion in an introduced plant.Evolutionary applications · 2024Article
- Divergent mechanisms of reduced growth performance in Betula ermanii saplings from high-altitude and low-latitude range edges.Heredity · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Why species have geographically restricted distributions is an unresolved question in ecology and evolutionary biology. Here, we test a new explanation that mutation accumulation due to small population size or a history of range expansion can contribute to restricting distributions by reducing population growth rate at the edge. We examined genomic diversity and mutational load across the entire geographic range of the North American plant Arabidopsis lyrata, including old, isolated populations predominantly at the southern edge and regions of postglacial range expansion at the northern and southern edges. Genomic diversity in intergenic regions declined toward distribution edges and signatures of mutational load in exon regions increased. Genomic signatures of mutational load were highly linked to phenotypically expressed load, measured as reduced performance of individual plants and lower estimated rate of population growth. The geographic pattern of load and the connection between load and population growth demonstrate that mutation accumulation reduces fitness at the edge and helps restrict species' distributions.
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