ArticlePloS one2018
Rapidly progressive dementia: An eight year (2008-2016) retrospective study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The evolving etiologies of rapidly progressive dementia: a systematic review.Translational psychiatry · 2025Pooled it
- Autoimmune Encephalitis as Treatment-Responsive Cause of Rapidly Progressive Dementia: A Multicenter Prospective Cohort Study.Neurology · 2026Observational
- Standardizing "Rapid": Applying the Clinical Dementia Rating to Define Rapidly Progressive Dementia.Neurology · 2026Article
- [Rapidly progressive dementia by late neurosyphilis (general paresis). Case report].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Improving Early Recognition of Treatment-Responsive Causes of Rapidly Progressive Dementia: The STAMAnnals of neurology · 2024Observational
- Clinical and Laboratory Characteristics, Diagnosis, and Treatment of Patients with Neurosyphilis in Emergency Department: A Retrospective Study of 12 Patients.Infection and drug resistance · 2024Article
- Prevalence and outcomes of rapidly progressive dementia: a retrospective cohort study in a neurologic unit in China.BMC geriatrics · 2023Article
- Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease with a Variety of Visual Symptoms: A Case Report with Autopsy Study.The American journal of case reports · 2023Article
- Neural Surface Antibodies and Neurodegeneration: Clinical Commonalities and Pathophysiological Relationships.Biomedicines · 2023Review
- Neuropsychological Features in Patients with General Paresis of the Insane at an Early Stage.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Rapidly progressive dementia in an elderly man.Practical neurology · 2022Article
- Development of a New Index to Distinguish Hepatic Encephalopathy through Automated Quantification of Globus Pallidal Signal Intensity Using MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Rapidly progressive dementias - aetiologies, diagnosis and management.Nature reviews. Neurology · 2022Review
- Rapidly progressive dementia: Extending the spectrum of GFAP-astrocytopathies?Annals of clinical and translational neurology · 2022Article
- Intravascular large B-cell lymphoma presenting as rapidly progressive dementia and stroke: A case report.Medicine · 2021Article
- Autoimmune Encephalitis Resembling Dementia Syndromes.Neurology(R) neuroimmunology & neuroinflammation · 2021Observational
- Autoimmune encephalopathies presenting as dementia of subacute onset and rapid progression.Therapeutic advances in neurological disorders · 2021Review
- Rapidly progressive dementia-associated N-type voltage-gated calcium channel antibody encephalopathy.Proceedings (Baylor University. Medical Center) · 2020Article
- An Evaluation of Rapidly Progressive Dementia Culminating in a Diagnosis of Creutzfeldt-Jakob Disease.Case reports in infectious diseases · 2018Article
- Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRapidly progressive dementia (RPD) is an emergency in cognitive neurology, defined as cognitive impairment affecting the daily living activities developed over less than 1 year. This study investigated the profile of patients with rapidly progressive dementia at first presentation.
methodsRetrospective case analysis was done in 187 patients with rapidly progressive dementia who presented to the Postgraduate Institute of Medical Education and Research, Chandigarh, India from January 2008 to August 2016. Patients were divided into three groups: (1) Reversible (treatable) secondary dementia group, (2) Prion dementia group (sporadic Creutzfeldt-Jakob disease), (3) Non-prion Neurodegenerative and vascular dementias (primary neurodegenerative and vascular dementia). Cases presenting with delirium secondary to metabolic, drug induced or septic causes and those with signs of meningitis were excluded.
resultsSecondary reversible causes formed the most common cause for RPD with immune mediated encephalitides, neoplastic and infectious disorders as the leading causes. The patients in this series had an younger onset of RPD. Infections presenting with RPD accounted for the most common cause in our series (39%) with SSPE (41%) as the leading cause followed by neurosyphilis (17.9%) and progressive multifocal leukoencephalopathy (15.3%). Immune mediated dementias formed the second most common (18.1%) etiologic cause for RPD. The neurodegenerative dementias were third common cause for RPD in our series. Neoplastic disorders and immune mediated presented early (< 6 months) while neurodegenerative disorders presented later (> 6 months).
conclusionsRapidly progressive dementia is an emergency in cognitive neurology with potentially treatable or reversible causes that should be sought for diligently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.