ArticlePLoS neglected tropical diseases2018
Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Individual-level agreement between coverage surveys and treatment registers in mass drug administration: A secondary analysis of the multi-country DeWorm3 cluster randomized trial.PLoS neglected tropical diseases · 2026Trial
- Coverage of community-wide mass drug administration platforms for soil-transmitted helminths in Benin, India, and Malawi: findings from the DeWorm3 project.Infectious diseases of poverty · 2024Trial
- Evaluation of opportunities to implement community-wide mass drug administration for interrupting transmission of soil-transmitted helminths infections in India.PLoS neglected tropical diseases · 2023Trial
- Policy stakeholder perspectives on barriers and facilitators to launching a community-wide mass drug administration program for soil-transmitted helminths.Global health research and policy · 2022Trial
- Trial
- Defining optimal implementation packages for delivering community-wide mass drug administration for soil-transmitted helminths with high coverage.BMC health services research · 2022Trial
- Trial
- Epidemiology of soil-transmitted helminths following sustained implementation of routine preventive chemotherapy: Demographics and baseline results of a cluster randomised trial in southern Malawi.PLoS neglected tropical diseases · 2021Trial
- Epidemiology of soil transmitted helminths and risk analysis of hookworm infections in the community: Results from the DeWorm3 Trial in southern India.PLoS neglected tropical diseases · 2021Trial
- Disparities in deworming coverage between children with and without disabilities: insights from the DeWorm3 trial in India.BMJ global health · 2026Article
- The Changing Face of Helminth Infections: A 15-Year Temporal Analysis from Eastern Saudi Arabia.Infection and drug resistance · 2025Article
- School-based deworming programmes: Knowledge and perceptions regarding soil-transmitted helminth infections among schoolteachers in Tamil Nadu, India.PLOS global public health · 2025Article
- Article
- Scaling up One Health: A network analysis in Lao PDR.One health (Amsterdam, Netherlands) · 2024Article
- Adolescents' Perspective Regarding a Community-Wide Mass Drug Administration Program for Soil-Transmitted Helminths in India.The American journal of tropical medicine and hygiene · 2024Article
- Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review.PLoS neglected tropical diseases · 2024Article
- "Our desire is to make this village intestinal worm free": Identifying determinants of high coverage of community-wide mass drug administration for soil transmitted helminths in Benin, India, and Malawi.PLoS neglected tropical diseases · 2024Article
- Identifying opportunities to optimize mass drug administration for soil-transmitted helminths: A visualization and descriptive analysis using process mapping.PLoS neglected tropical diseases · 2024Article
- Remote evaluation of STH program coverage: Experiences from the DeWorm3 study, India.PLoS neglected tropical diseases · 2023Article
- Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation-a Theory of Planned Behaviour analysis.PLoS neglected tropical diseases · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers that aim to rapidly translate study findings into evidence-based practice. The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions. The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. DeWorm3 will use stakeholder mapping to identify individuals who influence or are influenced by school-based or community-wide mass drug administration (MDA) for STH and to evaluate network dynamics that may affect study outcomes and future policy development. Individual interviews and focus groups will generate the qualitative data needed to identify factors that shape, contextualize, and explain DeWorm3 trial outputs and outcomes. Structural readiness surveys will be used to evaluate the factors that drive health system readiness to implement novel interventions, such as community-wide MDA for STH, in order to target change management activities and identify opportunities for sustaining or scaling the intervention. Process mapping will be used to understand what aspects of the intervention are adaptable across heterogeneous implementation settings and to identify contextually-relevant modifiable bottlenecks that may be addressed to improve the intervention delivery process and to achieve intervention outputs. Lastly, intervention costs and incremental cost-effectiveness will be evaluated to compare the efficiency of community-wide MDA to standard-of-care targeted MDA both over the duration of the trial and over a longer elimination time horizon.
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