ArticlePLoS biology2018
Structure, function, and control of the human musculoskeletal network.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Chronic Ankle Instability and Low Back Pain: A Narrative Review With a Conceptual Framework Linking Distal and Proximal Sensorimotor Dysfunction.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Review
- Motion as Medicine: Physical Activity, Joint Sensitivity, and Pain Management-A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness.eLife · 2026Article
- Environmental Micro-Nanoplastics and Musculoskeletal Disorders: Current Research and Insights.International journal of nanomedicine · 2026Review
- Stage-specific requirement for METTL3-dependent mCommunications biology · 2025Article
- From Myofascial Chains to the Polyconnective Network: A Novel Approach to Biomechanics and Rehabilitation Based on Graph Theory.Life (Basel, Switzerland) · 2025Article
- Spatially distributed biomimetic compliance enables robust anthropomorphic robotic manipulation.Communications engineering · 2025Article
- Alterations of upper-extremity functional muscle networks in chronic stroke survivors.Experimental brain research · 2024Article
- An inclusive anatomical network analysis of human craniocerebral topology.Journal of anatomy · 2024Article
- Hypergraph modeling of complex interactions: Applications from human musculoskeletal structures to complex system dynamics.PloS one · 2024Article
- Orthopedic Research Funding: Assessing the Relationship between Investments and Breakthroughs.Orthopedic reviews · 2024Article
- A roadmap for delivering a human musculoskeletal cell atlas.Nature reviews. Rheumatology · 2023Review
- Effects of tDCS on Foot Biomechanics: A Narrative Review and Clinical Applications.Bioengineering (Basel, Switzerland) · 2023Review
- A comprehensive anatomical network analysis of human brain topology.Journal of anatomy · 2023Article
- Space Environment Impacts Homeostasis: Exposure to Spaceflight Alters Mammary Gland Transportome Genes.Biomolecules · 2023Article
- Body Weight Control Is a Key Element of Motor Control for Toddlers' Walking.Frontiers in network physiology · 2022Article
- Primitive muscle synergies reflect different modes of coordination in upper limb motions.Medical & biological engineering & computing · 2021Article
- Morphometric analysis of vastus medialis oblique muscle and its influence on anterior knee pain.Anatomy & cell biology · 2021Article
- Mapping the rest of the human connectome: Atlasing the spinal cord and peripheral nervous system.NeuroImage · 2021Review
- An Emerging Preventive Mental Health Care Strategy: The Neurobiological and Functional Basis of Positive Psychological Traits.Frontiers in psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understanding of this network and its control by neural systems has remained elusive. Here we address this gap in knowledge by utilizing medical databases and mathematical modeling to reveal the organizational structure, predicted function, and neural control of the musculoskeletal system. We constructed a highly simplified whole-body musculoskeletal network in which single muscles connect to multiple bones via both origin and insertion points. We demonstrated that, using this simplified model, a muscle's role in this network could offer a theoretical prediction of the susceptibility of surrounding components to secondary injury. Finally, we illustrated that sets of muscles cluster into network communities that mimic the organization of control modules in primary motor cortex. This novel formalism for describing interactions between the muscular and skeletal systems serves as a foundation to develop and test therapeutic responses to injury, inspiring future advances in clinical treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.