Evidence map›Paper›PMID 29346317›Full record

ArticleMolecules (Basel, Switzerland)2018

Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells.

Sumit Mukherjee, Juliet N E Baidoo, Samay Sampat, Andrew Mancuso, Lovena David, Leah S Cohen, Shuiqin Zhou, Probal Banerjee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sumit MukherjeePh.D. Program in Biochemistry, The Graduate Center, City University of New York, New York, NY 10016, USA. smukherjee@gradcenter.cuny.edu.ORCID 0000-0003-0382-450X
Juliet N E BaidooPh.D. Program in Biochemistry, The Graduate Center, City University of New York, New York, NY 10016, USA. Juliet.Baidoo@csi.cuny.edu.
Samay SampatCollege of Arts and Science, New York University, New York, NY 10003, USA. samay.sampat@gmail.com.
Andrew MancusoPh.D. Program in Biochemistry, The Graduate Center, City University of New York, New York, NY 10016, USA. Andrew.Mancuso@csi.cuny.edu.
Lovena DavidCenter for Developmental Neuroscience, City University of New York, The College of Staten Island, Staten Island, NY 10314, USA. lovenagrace@yahoo.com.
Leah S CohenDepartment of Chemistry, City University of New York, The College of Staten Island, Staten Island, NY 10314, USA. Leah.Cohen@csi.cuny.edu.
Shuiqin ZhouDepartment of Chemistry, City University of New York, The College of Staten Island, Staten Island, NY 10314, USA. Shuiqin.Zhou@csi.cuny.edu.
Probal BanerjeeDepartment of Chemistry, City University of New York, The College of Staten Island, Staten Island, NY 10314, USA. probal.banerjee@csi.cuny.edu.
College of Staten Island · USThe Graduate Center, CUNY · USNew York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is a deadly brain tumor with a current mean survival of 12-15 months. Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. We have reported earlier a strategy involving the use two other polyphenols, epicatechin gallate (E) from green tea and resveratrol (R) from red grapes at a unique, synergistic molar ratio with C (C:E:R: 4:1:12.5, termed TriCurin) to achieve superior potency against HPV+ tumors than C alone at C:E:R (μM): 32:8:100 (termed 32 μM+ TriCurin). We have now prepared liposomal TriCurin (TrLp) and demonstrated that TrLp boosts activated p53 in cultured GL261 mouse GBM cells to trigger apoptosis of GBM and GBM stem cells in vitro. TrLp administration into mice yielded a stable plasma concentration of 210 nM C for 60 min, which, though sub-lethal for cultured GL261 cells, was able to cause repolarization of M2-like tumor (GBM)-associated microglia/macrophages to the tumoricidal M1-like phenotype and intra-GBM recruitment of activated natural killer cells. The intratumor presence of such tumoricidal immune cells was associated with concomitant suppression of tumor-load, and apoptosis of GBM and GBM stem cells. Thus, TrLp is a potential onco-immunotherapeutic agent against GBM tumors.

Indexed as

Drug CombinationsLiposomesAnimalsBiomarkers, TumorCatechinCell Line, TumorCurcuminDisease Models, AnimalDrug SynergismGlioblastomaHumansImmunophenotypingKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMacrophagesMiceBiomarkers, TumorCatechinCurcuminDrug Combinationsepicatechin gallateLiposomesResveratrolStilbenesTumor Suppressor Protein p53curcuminepicatechin gallateGBM stem cellsglioblastoma multiforme (GBM)liposomesNK cellsresveratrolTriCurintumor-associated microglia/macrophages (TAM)

Identifiers

PMID29346317
PMCPMC6017476
OpenAlexW2793640805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.