Evidence map›Paper›PMID 29346163›Full record

ReviewExercise and sport sciences reviews2018

The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function.

Kevin I Watt, Craig A Goodman, Troy A Hornberger, Paul Gregorevic

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Kevin I WattBaker Heart and Diabetes Institute.
Craig A GoodmanBaker Heart and Diabetes Institute.
Troy A HornbergerBaker Heart and Diabetes Institute.
Paul GregorevicBaker Heart and Diabetes Institute.
Australian Institute for Musculoskeletal Science · AUBaker Heart and Diabetes Institute · AUFred Hutch Cancer Center · USMonash University · AU

Funding

Mechanotransduction and the Regulation of Skeletal Muscle MassR01AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2010 to 2019
$3.6M
The Role of TCTP in the Regulation of Skeletal Muscle MassR21AR063256 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOODMAN, CRAIG ANDREW, HORNBERGER, TROY A · 2012 to 2013
$364k
Mechanotransduction and the Regulation of Skeletal Muscle MassR56AR057347 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORNBERGER, TROY A · 2022 to 2022
$270k
NIAMS NIH HHS R01 AR057347NIAMS NIH HHS R21 AR063256NIAMS NIH HHS R56 AR057347
6 · The paper itself

Abstract

The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.

Indexed as

Resistance TrainingSignal TransductionAdaptation, PhysiologicalCell Cycle ProteinsDNA-Binding ProteinsGene ExpressionHippo Signaling PathwayHumansIntracellular Signaling Peptides and ProteinsMuscle Fibers, SkeletalMuscle, SkeletalNuclear ProteinsProtein Serine-Threonine KinasesTEA Domain Transcription FactorsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsCell Cycle ProteinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsNuclear ProteinsProtein Serine-Threonine KinasesTEAD1 protein, humanTEA Domain Transcription FactorsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanYY1AP1 protein, human

Identifiers

PMID29346163
PMCPMC6319272
OpenAlexW2790351327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.